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Research Article Open access CC BY 4.0

Determination of Red Blood Cells Trace Elements as Risk Factors for Breast Cancer by X-Ray Fluorescence

Alkhansa Salih Mahmoud, Khalda Awad Albadwa, Khalid Hussein Bakheit

International Journal of Biochemistry Research & Review · pp. 74–80 · Published 21 Nov 2022

10.9734/ijbcrr/2022/v31i10789

Abstract

Introduction: Breast cancer is a heterogeneous disease that cause women death. Several factors influence the development of breast cancer. Trace elements are associated with breast cancer risk factors. This study investigated six trace elements in red blood cells of women newly diagnosed with breast cancer, compared to healthy women. Methods: 38 Sudanese women participated in this study; 19 of them were breast cancer patients, who were compared with 19 healthy women of the same age to determine the concentrations of K, Zn, Cu, Fe, Ca, and Pb in red blood cells by X-ray fluorescence. Results: K concentration was significantly increased in breast cancer patients compared to the control group (P= < 0.001). Zn and Cu were slightly decreased in patients compared to the control group. In contrast, insignificant increase was observed for Fe, Ca and Pb in breast cancer patients compared to the control group. Correlations between Fe and Cu, K and Pb were found in breast cancer patients. Conclusion: High K concentration in red blood cells is associated with breast cancer risk in Sudanese women. K can be used as a biomarker for breast cancer prognosis and development.

Red blood cells trace elements risk factors breast cancer

References (29)

  1. 1 Analytical and bioanalytical chemistry
  2. 2 Epidemiology of breast cancer [DOI]
  3. 3 Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome [DOI]
  4. 4 Zinc in innate and adaptive tumor immunity [DOI]
  5. 5 Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China [DOI]
  6. 6 Understanding copper homeostasis in humans and copper effects on health [DOI]
  7. 7 The molecular basis of copper and iron interactions [DOI]
  8. 8 Pseudohyperkalemia in Serum: A New Insight into an Old Phenomenon [DOI]
  9. 9 Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: An Indian study☆ [DOI]
  10. 10 Serum Trace Elements and Their Associations with Breast Cancer Subgroups in Korean Breast Cancer Patients [DOI]
  11. 11 Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria [DOI]
  12. 12 Serum and hair zinc levels in breast cancer: a meta-analysis [DOI]
  13. 13 Determination of Ca, Fe, Cu and Zn and their correlations in breast cancer and normal adjacent tissues [DOI]
  14. 14 Calcium, Magnesium, and Other Elements in the Red Blood Cells and Hair of Normals and Patients with Premenstrual Syndrome [DOI]
  15. 15 Relationship between selenium and breast cancer: a case-control study in the Klang Valley.
  16. 16 Plasma micronutrients, trace elements, and breast cancer in BRCA1 mutation carriers: an exploratory study [DOI]
  17. 17 A novel total reflection X-ray fluorescence procedure for the direct determination of trace elements in petrochemical products [DOI]
  18. 18 Analysis of plasma and erythrocyte zinc levels in premenopausal women with breast cancer. [DOI]
  19. 19 Erythrocyte concentrations of chromium, copper, manganese, molybdenum, selenium and zinc in subjects with different physical training levels [DOI]
  20. 20 Emerging drugs for hyperphosphatemia [DOI]
  21. 21 Management of tumor lysis syndrome in adults [DOI]
  22. 22 Heavy metal modulation of lymphocyte activities—II. lead, an in vitro mediator of B-cell activation [DOI]
  23. 23 Atomic spectrometry update. X-ray fluorescence spectrometry [DOI]
  24. 24 Immune function of bovine leukocytes after in vitro exposure to selected heavy metals [DOI]
  25. 25 A preliminary study of the distribution of trace elements in healthy and neoplastic breast tissues with synchrotron radiation X-ray fluorescence [DOI]
  26. 26 Tumor Lysis Syndrome and Acute Kidney Injury: Evaluation, Prevention, and Management [DOI]
  27. 27 Association between VDR Gene Polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820) and Susceptibility to Breast Cancer in a Sample of Southeastern Iranian Population [DOI]
  28. 28 [Zinc deficiency. Symptoms, causes, diagnosis and therapy].
  29. 29 X–Ray Based Methods of Analysis [DOI]

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