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Research Article Open access CC BY 4.0

Effect of Aqueous Extract of Vernonia amygdalina on Biochemical Indices of Prostate Functions in Hormonal Induced Enlarged Prostate in Rats

Melvin Nnaemeka Ugwu, Mary Achi Mgbekem, Mbeh Ubana Eteng

Journal of Complementary and Alternative Medical Research · pp. 1–12 · Published 14 Jul 2018

10.9734/JOCAMR/2018/42506

Abstract

Background: Benign prostate hyperplasia (BPH) is a common urological disorder in elderly men. We investigated the effect of aqueous extract of Vernonia amygdalina (VA) on BPH. Methods: BPH was induced in male rats weighing 250-350 g. Testosterone propionate (T) and estradiol valerate (E2) were used for the induction at a dose of 400 µG T and 80 µG E2 respectively. This was administered to the rats for three weeks subcutaneously in the inguinal region. A total of 30 rats were divided into five groups. One group was used as a control and the other groups received subcutaneous injections of the hormones for 3 weeks to induce BPH. Groups 1 and 2 were treated with different doses of VA extracts and group 3 received finasteride, all by gavages for forty-five days, while group 4 was left untreated, group 5 served as normal control. After forty-five days of treatment with VA extract, the rats were anaesthetised by short contact with trichloromethane vapour. Blood was collected by cardiac puncture and the sera cautiously centrifuged and used for the determination of different biochemical indices. The prostate was harvested and weighed. The harvested prostate were processed for paraffin embedding and stained with H and E. Results: Treatment with the extract and finasteride resulted to significant (P < 0.05) decrease in prostate-specific antigen (PSA), estradiol and prolactin, testosterone and protein content of the prostate when compared to BPH control. Prostate weight was significantly (P < 0.05) reduced in treated groups compared to BPH control. This was supported by the histological examination. Conclusion: Therefore, Vernonia amygdalina was effective in reducing PSA, prolactin, testosterone, estradiol and prostate weight induced BPH in a rat model, and may be useful for the clinical treatment of patients with BPH.  

Estradiol PSA prostate testosterone and Vernonia amygdalina

References (28)

  1. 1 Phytochemical Screening and Antioxidant Activities of Some Selected Medicinal Plants Used for Malaria Therapy in Southwestern Nigeria [DOI]
  2. 2 Antioxidative and Chemopreventive Properties of Vernonia amygdalina and Garcinia biflavonoid [DOI]
  3. 3 In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo [DOI]
  4. 4 Contribution to the ethnobotanical, phytochemical and pharmacological studies of traditionally used medicinal plants in the treatment of dysentery and diarrhoea in Lomela area, Democratic Republic of Congo (DRC) [DOI]
  5. 5 Bioactive sesquiterpene lactones from the leaves of Vernonia amygdalina [DOI]
  6. 6 Efficacy of aqueous leaf extract of vernonia amygdalina on plasma lipoprotein and oxidative status in diabetic rat models.
  7. 7 The Influence of Baseline Parameters on Changes in International Prostate Symptom Score with Dutasteride, Tamsulosin, and Combination Therapy among Men with Symptomatic Benign Prostatic Hyperplasia and an Enlarged Prostate: 2-Year Data from the CombAT Study [DOI]
  8. 8 Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. [DOI]
  9. 9 Relationship Between Serum Testosterone and Measures of Benign Prostatic Hyperplasia in Aging Men [DOI]
  10. 10 Hypoglycemic potentials of methanolic extracts of selected plant foods in alloxanized mice [DOI]
  11. 11 Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases [DOI]
  12. 12 Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia [DOI]
  13. 13 Pharmacological effects of the lipidosterolic extract ofSerenoa repens (Permixon�) on rat prostate hyperplasia induced by hyperprolactinemia: Comparison with finasteride [DOI]
  14. 14 Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation [DOI]
  15. 15 Serenoa repens extract in the treatment of benign prostatic hyperplasia [DOI]
  16. 16 Relative influence of testosterone and insulin in the regulation of prostatic cell proliferation and growth [DOI]
  17. 17 An interaction between carotene‐15,15′‐monooxygenase expression and consumption of a tomato or lycopene‐containing diet impacts serum and testicular testosterone [DOI]
  18. 18 Prostate Specific Antigen, Antioxidant and Hematological Parameters in Prostatic Rats Fed Solanum macrocarpon L. Leaves [DOI]
  19. 19 Economic issues and the management of benign prostatic hyperplasia [DOI]
  20. 20 Hepatoprotective Effect of Ethanolic Leaf Extract of Vernonia amygdalina and Azadirachta indica against Acetaminophen-Induced Hepatotoxicity inSprague-Dawley Male Albino Rats [DOI]
  21. 21 The effects of ethanol extract of Raphia hookeri seed on exogenous testosterone and estradiol induced benign prostatic hyperplasia in adult male rats [DOI]
  22. 22 Histomorphological changes in induced benign prostatic hyperplasia with exogenous testosterone and estradiol in adult male rats treated with aqueous ethanol extract of Secamone afzelii [DOI]
  23. 23 Protective Effect of Some Tropical Vegetables Against CCl 4 -Induced Hepatic Damage [DOI]
  24. 24 Current Status of 5α-Reductase Inhibitors in Prostate Disease Management [DOI]
  25. 25 A sensitive solid phase enzymeimmunoassay for testosterone in plasma and saliva [DOI]
  26. 26 Increased Risk of Benign Prostatic Enlargement Among Patients With Liver Cirrhosis: A Nationwide Population‐Based Study [DOI]
  27. 27 QUALITATIVE ANALYSIS OF SERUM PROTEINS IN BENIGN PROSTATIC HYPERPLASIA SEPARATED BY SDS-PAGE
  28. 28 Inflammation, Apoptosis, and BPH: What is the Evidence? [DOI]

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