Effect of Ethanol Extract of Abrus precatorious Seed on Testosterone-Induced Benign Prostatic Hyperplasia in Adult Male Wistar Rats
I. I. Bello, O. T. Kunle-Alabi, T. F. Abraham, Y. Raji
Journal of Cancer and Tumor International · pp. 1–11 · Published 20 Oct 2017
10.9734/JCTI/2017/34832Abstract
Aim: To assess the effects of Abrus precatorious seed extract on prostate weight and hormonal levels (dihydrotestosterone, testosterone and estrogen) of male Wistarrats. Study Design: The study was divided into six groups A, B, C, D, E and F. Place and Duration of Study: The study was conducted at Department of Physiology, College of Medicine, University of Ibadan between February and March, 2016. Methodology: Thirty adult male rats were divided into six groups (n=5). Group A received water orally and groups C and D received 40 and 60 mg/kg of extract orally for 28 days respectively. Benign prostatic hyperplasia was induced in groups B, E and F via subcutaneous injection of 3 mg/kg of testosterone. Groups E and F received concurrently 40 and 60 mg/kg of extract orally for 28 days respectively. Hormonal levels, epididymis, testis and prostate weight were determined. Sperm analysis and histological analysis of the testis and prostate were conducted. Results: Relative prostate weight decreased (P= .05) in groups C (0.022 ± 0.0025) and D (0.016 ± 0.0029) when compared to group A (0.0730 ± 0.0058), and in groups E (0.080 ± 0.0084) and F (0.096 ± 0.0075) when compared to group B (0.14±0.0016). The serum estrogen level decreased in groups E (16.20 ± 0.80) and F (16.40 ± 0.51) as compared to group B (19.40 ± 1.33), and also in groups C (11.80 ± 0.66) and D (11.60 ± 0.51) when compared to group A (15.20± 0.58). Prostate dihydrotestosterone levels increased in groups C and D compared to group A, and in groups E and F compared to group B. There was severe cystic prostate hyperplasia in group B. Conclusion: Abrus precatorious seed has potential to reduce severity of testosterone-induced BPH.
References (27)
- 1 Manual of histologic staining methods of the Armed forces institute of pathology
- 2 Identification of Specific Sites of Hormonal Regulation in Spermatogenesis in Rats, Monkeys, and Man [DOI]
- 3 BPH: epidemiology and comorbidities.
- 4 A New Era of Testosterone and Prostate Cancer: From Physiology to Clinical Implications [DOI]
- 5 Lauric acid and myristic acid prevent testosterone induced prostatic hyperplasia in rats [DOI]
- 6 Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract.
- 7 Ameliorative effects of stinging nettle (Urtica dioica) on testosterone-induced prostatic hyperplasia in rats [DOI]
- 8 Structure-Function Analysis and Insights into the Reduced Toxicity of Abrus precatorius Agglutinin I in Relation to Abrin [DOI]
- 9 Estrogen-regulated development and differentiation of the prostate [DOI]
- 10 Dose–response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate [DOI]
- 11 Curcumin Attenuates Gastric Cancer Induced by N -Methyl- N -Nitrosourea and Saturated Sodium Chloride in Rats [DOI]
- 12 Prospective Study of Serum Dihydrotestosterone and Subsequent Risk of Benign Prostatic Hyperplasia in Community Dwelling Men: The Rancho Bernardo Study [DOI]
- 13 Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia.
- 14 Sperm antimotility properties of a seed extract of Abrus precatorius [DOI]
- 15 THE SELECTIVITY AND SPECIFICITY OF THE ACTIONS OF THE LIPIDO-STEROLIC EXTRACT OF SERENOA REPENS (PERMIXON®) ON THE PROSTATE [DOI]
- 16 Aetiology and pathogenesis of benign prostatic hyperplasia [DOI]
- 17 Oestrogen and benign prostatic hyperplasia: effects on stromal cell proliferation and local formation from androgen [DOI]
- 18 Protective effects of Echinops echinatus on testosterone-induced prostatic hyperplasia in rats [DOI]
- 19 Association between polymorphisms of estrogen receptor 2 and benign prostatic hyperplasia [DOI]
- 20 Alpha2Adrenergic Receptors in Hyperplastic Human Prostate: Identification and Characterization Using [3H] Rauwolscine [DOI]
- 21 Clinical features and management of anterior intraurethral prostatic cyst [DOI]
- 22 Effects of Cyproterone Acetate on Mating Behavior, Testicular Morphology, Testosterone Level, and Body Temperature in Male Ferrets in Comparison with Normal and Castrated Males [DOI]
- 23 Prostatic cyst causing severe infravesical obstruction in a young patient.
- 24 Managing benign prostatic hyperplasia and prostate cancer – the challenges today [DOI]
- 25 Dissociating Behavioral, Autonomic, and Neuroendocrine Effects of Androgen Steroids in Animal Models [DOI]
- 26 Development of a model for the induction of estrogen‐related prostatic hyperplasia in the dog and its response to the aromatase inhibitor 4‐hydroxy‐4‐androstene‐3,17‐dione: Preliminary results [DOI]
- 27 Screening of some indigenous medicinal plants for anti-implantation/anti-fertility activity in female albino rats.
Cited by 7
Basma H. Marghani, Alaa Fehaid, Ahmed I. Ateya · Life Sciences · 2022
Idris Idowu Bello, Akinyinka O. Omigbodun, Imran O Morhason-Bello · 2022
Idris Idowu Bello, Akinyinka Omigbodun, Imran Morhason-Bello · BMC Urology · 2023
Showing 3 of 7 known citations — external sources report more than can currently be individually listed.
Related research
- Trace Elements, Antioxidants, Uric Acid, C-Reactive Proteins and Estrogen Levels of Preeclamptic Pregnant Women in Owerri, Nigeria — shares topic coverage
- Effect of Apple Cider Vinegar (ACV) “With Mother” on Progesterone, Testosterone and Estrogen of Wistar Rats — shares topic coverage
- The Effect of Nigella sativa and Piper guineense Aqueous Extracts on the in Vivo Expression Profile of Lipid and Sex Hormones — shares topic coverage
- Effects of Estrogen and Folic Acid on High Fat Induced Hypercholesterolemic Mice — shares topic coverage
- Female Athlete Triad: Understanding the Interrelationship between Energy Availability, Menstrual Function, and Bone Health — shares topic coverage
Article metrics
Real usage data collected on this platform.
40
Page views
0
PDF downloads
4
Outbound clicks
7
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.