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Research Article Open access CC BY 3.0

Effect of Leaf Essential Oil of Citrus sinensis on Haematological Parameters of Alloxan-induced Diabetic Rats

O. Soji-Omoniwa, N. O. Muhammad, B. P. Omoniwa, L. A. Usman

International Blood Research & Reviews · pp. 113–120 · Published 22 Feb 2014

10.9734/IBRR/2014/7952

Abstract

Aim: The aim of this study was to investigate the effect of leaf essential oil of Citrus sinensis (Rutaceae) on haematological parameters of alloxan – induced diabetic rats. Methodology: Diabetes was induced in albino rats by intraperitoneal administration of single dose of alloxan monohydrate (150 mg/kg body weight). The leaf essential oil of Citrus sinensis at a dose of 110 mg/kg b.wt was administered every other day to the diabetic rats during 15 days. The effects of leaf essential oil on the erythrocyte and leucocyte indices were then evaluated. Results: Red Blood Cell, Packed Cell Volume, White blood cell, Neutrophils and Leucocytes were reduced significantly in diabetic animals. However, treatment with leaf oil of C. sinensis increased these parameters subsequently. Conclusion: It is concluded that leaf essential oil of Citrus sinensis improved the erythrocyte and leucocyte indices of diabetic rats.

Erythrocyte Leucocyte Citrus sinensis Rutaceae essential oil diabetic rats

References (18)

  1. 1 Global Prevalence of Diabetes [DOI]
  2. 2 Antioxidant activity of flavonoids and reactivity with peroxy radical [DOI]
  3. 3 Practical Haematology [DOI]
  4. 4 Methods to study the phytochemistry and bioactivity of essential oils [DOI]
  5. 5 Correlation between total phenolic and mineral contents with antioxidant activity of eight Malaysian bananas (Musa sp.) [DOI]
  6. 6 Oxidative stress in diabetes mellitus [DOI]
  7. 7 Antidiabetic and haematological effect of aqueous extract of stem bark of Afzelia africana (Smith) on streptozotocin–induced diabetic Wistar rats [DOI]
  8. 8 DIABETES AND HERBAL MEDICINES
  9. 9 Antidiabetic activities of aqueous leaves extract of Leonotis leonurus in streptozotocin induced diabetic rats [DOI]
  10. 10 Fruit of the jambolan tree (Eugenia jambolana Lam.) and experimental diabetes [DOI]
  11. 11 The detailed analysis of essential oils leads to the understanding of their properties
  12. 12 Oxidative Stress in Diabetes Mellitus [DOI]
  13. 13 Improvement of insulin sensitivity by perindopril in spontaneously hypertensive and streptozotocin-diabetic rats
  14. 14 Chemical composition of the essential oils of Citrus sinensis cv. valencia and a quantitative structure-retention relationship study for the prediction of retention indices by multiple linear regression [DOI]
  15. 15 Effect of an acute zinc depletion on rat lipoprotein distribution and peroxidation [DOI]
  16. 16 Effect of aqueous extract of Leonotis leonurus (L.) R. Br. leaves in male Wistar rats [DOI]
  17. 17 Haematological Parameters of Broiler Chicks Fed Aspergillus niger - Fermented Terminalia catappa Seed Meal-Based Diet
  18. 18 Correlation of Lipid Peroxidation with Glycated Haemoglobin Levels in Diabetes Mellitus

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