Effect of Neem Extract with Zinc Oxide Nanoparticles for Burn Wound Treatment
Md. Rashid Anjum, Rakibul Islam, Md. Mahmudul Hasan, Bazlar Rashid, Mst. Misrat Masuma Parvez, Sumon Sarkar, Md. Hannan Ali, Mst. Eshrat Zahan Asha
Journal of Applied Life Sciences International · pp. 17–23 · Published 31 Jan 2023
10.9734/jalsi/2023/v26i1593Abstract
A study was conducted to determine the clinical efficiency of neem extract with Zinc Oxide (ZnO) nanoparticles on burn wound healing treatment in Rabbit model. Sixteen (16) male New Zealand white rabbits were assigned into four groups, each with four rabbits, and were kept together for 28 days. Group T0 as the control; T1 represented burn healing using neem extract; T2 represented burn healing using neem extract with ZnO nanoparticles; and T3 represented burn healing using a commercial drug (Bactrocin®). Data were accumulated on the healing rate, healing time, and WBC count. Healing rate was calculated at weekly interval and the healing time was observed regularly and calculated from day 7 at weekly interval and WBC count were investigated using an auto analyzer. The result showed that the healing rate (%) were T2 group= 93.75±1.25, T3 group=86.75±0.479, T1 group=84.25±1.75, and T0 group=70.75±2.25. Among this result the healing rate increased significantly in T2 (93.75±1.25) group, better by T3 (86.75±0.479), good by T1 (84.25±1.75) and worst by T0 (70.75±2.25) group. The application of neem extract with ZnO nanoparticles have also showed the quickest healing time (24.5±0.64 day) significantly (P<0.01). At weekly interval WBC count (cells/µl) was varied significantly, the highest value was discovered in the T2 group. The study's overall findings demonstrated that using neem extract with ZnO nanoparticles resulted in faster wound healing with a shorter time requirement. It indicates that wound healing without the use of antibiotics was possible and using neem extract can be advised for the treatment of burn wounds.
References (19)
- 1 Wound Repair and Regeneration [DOI]
- 2 Biological activities and medicinal properties of neem (Azadirachta indica)
- 3 Novel microbial route to synthesize ZnO nanoparticles using Aeromonas hydrophila and their activity against pathogenic bacteria and fungi [DOI]
- 4 Zinc oxide nanoparticles: Biological synthesis and biomedical applications [DOI]
- 5 Green synthesized ZnO nanoparticles against bacterial and fungal pathogens [DOI]
- 6 Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates [DOI]
- 7 Neem—An Omnipotent Plant: A Retrospection [DOI]
- 8 Basic science of wound healing [DOI]
- 9 Evidence supporting zinc as an important antioxidant for skin [DOI]
- 10 An overview of the plant-mediated synthesis of zinc oxide nanoparticles and their antimicrobial potential [DOI]
- 11 Physiological Role of Antioxidants in the Immune System [DOI]
- 12 Skin-Derived Precursor Cells Promote Wound Healing in Diabetic Mice [DOI]
- 13 Antioxidant activity of commonly consumed vegetables in yemen.
- 14 Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure [DOI]
- 15 Acute toxicity of Zinc Oxide nanoparticles to silkworm (Bombyx mori L.) [DOI]
- 16 Effect of dietary supplementation of neem oil (Azadirachtaindica) on the growth performance and nutrient digestibility of weaned rabbits [DOI]
- 17 [Chronic wounds: differential diagnosis].
- 18 Efficacy Of Some Indigenous Medicines In Wound Healing In Rats
- 19 Effect of dietary supplementation of neem oil (Azadirachtaindica) on the growth performance and nutrient digestibility of weaned rabbits [DOI]
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