Effects of Aloe barbadensis and Cymbopogon citratus on Blood Glucose Levels of Alloxan–Induced Diabetic Albino Rats
V. O. Offor, A. N. Ufele, B. U. Ononye, U. C. Aghalu, P. I. Afoemezie, E. I. Azaka, C. F. Chude
Journal of Complementary and Alternative Medical Research · pp. 44–51 · Published 5 May 2023
10.9734/jocamr/2023/v21i3441Abstract
Diabetes is a heterogeneous complex metabolic disorder characterized by elevated blood glucose concentration, and glycosuria resulting from insulin deficiency. This project was embarked upon to investigate the effects of Aloe barbadensis and Cymbopogon citratus on blood glucose levels of alloxan – induced diabetic adult albino rats. The 24-hour acute toxicity test (LD50) of the orally administered combined Aloe vera and lemon grass ethanolic extract was determined using the Lorke’s method. The fasting blood glucose levels were determined using glucose strips and glucometer. The toxicity test revealed that LD50 of the combined ethanolic extract of C. citratus and A. barbadensis was >5.0g/kg body weight. The result showed a significant (P<0.05) increase in the fasting blood glucose levels of the diabetic untreated animals compared with the fasting blood glucose levels of the normal control animals after inducing diabetes. There was also a significant (P<0.05) decrease in the fasting blood glucose levels of the animals treated with ethanolic extract of Aloe vera gel, lemon grass leaves and its combination when compared with the diabetic untreated. It could be concluded that that Aloe vera, lemon grass or its combination can be used as an alternative medicine for the treatment and management of diabetes mellitus.
References (7)
- 1 Global status report on noncommunicable diseases 2010.
- 2 Medicinal Plants with Antidiabetic Potential - A Review
- 3 Effect of Aloe vera and metformin on diabetic albino rats [DOI]
- 4 Effect of Cymbopogon citratus (Lemon grass) on the Expression of Insulin sensitive and Proinflammatory Genes in the Pancreas of Diabetic Rats [DOI]
- 5 Effect of Mixed Aqueous Extracts of Allium sativum, Annona muricata and Cymbopogon citratus Leaves on the Blood Glucose and Lipid Profile of Hyperglycemic Rats [DOI]
- 6 International Diabetes Federation (IDF) [DOI]
- 7 International Journal of Environmental Science and Technology [DOI]
Cited by 3
W. Makena, M. Nwankwo, Aisha Idris · Phytomedicine Plus · 2026
Patrycja Kula, G. Chladek, I. Barszczewska-Rybarek · International Journal of Molecular Sciences · 2025
Showing 2 of 3 known citations — external sources report more than can currently be individually listed.
Related research
- First Trimester Fasting Blood Glucose as a Screening Tool for Diabetes Mellitus in a Teaching Hospital Setting in Nigeria — shares topic coverage
- Impact of the Diet Profile and Alcohol Consumption on Cardiometabolic Risks in Dschang Health District-Cameroon — shares topic coverage
- Effect of Aqueous Extract of Persea americana Seed on Blood Glucose in Alloxan-induced Diabetic Wistar Rats — shares topic coverage
- Metal Based α-glucosidase Inhibitors: Synthesis, Characterization and α-glucosidase Inhibition Activity of Transition Metal Complexes — shares topic coverage
- Evaluation of Fluid Therapy by Point-of-Care Ultrasound in Hyperglycemic Emergencies — shares topic coverage
Article metrics
Real usage data collected on this platform.
44
Page views
0
PDF downloads
1
Outbound clicks
3
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.