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Research Article Open access CC BY 4.0

Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat

Ronald À. Goufani Bidingha, Danielle Claude Bilanda, Mireille Flore Metchi Donfack, Bibi-Farouck Aboubakar Oumarou, Lohik Mbolang Nguegan, Pascal Emmanuel Owona, Yannick Carlos Tcheutchoua, Paul Désiré Dzeufiet Djomeni, Théophile Dimo, Pierre Kamtchouing

Journal of Complementary and Alternative Medical Research · pp. 33–50 · Published 27 Aug 2022

10.9734/jocamr/2022/v19i130368

Abstract

Background and Aim: Cardiovascular complications are the main cause of morbidity and mortality in hypertensive diabetic patients. They develop due to microvasculopathy, myocardial hypertrophy and cardiac fibrosis. In the present study, the activity of aqueous extract of Erythrina senegalensis on cardiovascular complications in diabetic hypertensive rats was evaluated. Experimental Procedure: The model of hypertensive diabetic rats was obtained by daily oral administration of sucrose (15%) and 40° ethanol at doses of 1.5 and 5 g/kg respectively for six weeks, followed by an intravenous injection of streptozotocin (35 mg/kg). After four weeks of complications, the diabetic hypertensive rats were divided into six groups of 5 animals each, and received the different treatments for four weeks where blood glucose level was taken weekly. At the end of the treatments, the animals were anaesthetised and the arterial pressures and electrocardiograph were recorded by the direct method. Then the aorta and heart were removed for biochemical calorimetric analysis and histological evaluation. Results and Conclusion: In the diabetic hypertensive animals the results showed chronic hyperglycaemia associated with high blood pressure. On the electrocardiogram there was a cardiac arrhythmia manifested by a significant decrease in the duration of the PR, QRS, RR, QTc segments, ST interval, P, QRS and T waves, a decrease in the amplitude of the QRS and T waves. There was a significant increase in total cholesterol, triglyceride atherogenic index and a decrease in HDL-cholesterol with a change in the cardiac ionogram and oxidative status in the aorta and heart. The different treatments improved these parameters and cardiovascular function. These results suggest that the extract of E. senegalensis by the presence of several bioactive compounds would possess cardioprotective, hypoglycaemic, hypotensive and antioxidant properties.

Hypertension diabetes electrocardiograph cardiovascular complications Erythrina senegalensis rats

References (36)

  1. 1 DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTION [DOI]
  2. 2 Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids [DOI]
  3. 3 Archives of Biochemistry and Biophysics [DOI]
  4. 4 Diabetes research and clinical practice [DOI]
  5. 5 The thiobarbituric acid reagent as a test for the oxidation of unsaturated fatty acids by various agents.
  6. 6 Alcohol-induced hypertension: Mechanism and prevention [DOI]
  7. 7 Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction [DOI]
  8. 8 High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling [DOI]
  9. 9 Pharmacological potential of the combination of Salvia miltiorrhiza (Danshen) and Carthamus tinctorius (Honghua) for diabetes mellitus and its cardiovascular complications [DOI]
  10. 10 The increasing detection of asymptomatic left ventricular dysfunction in patients with type 2 diabetes mellitus without overt cardiac disease: Data from the SHORTWAVE study [DOI]
  11. 11 Low Lipid Levels and High Variability are Associated With the Risk of New‐Onset Atrial Fibrillation [DOI]
  12. 12 Green tea impedes dyslipidemia, lipid peroxidation, protein glycation and ameliorates Ca2+-ATPase and Na+/K+-ATPase activity in the heart of streptozotocin-diabetic rats [DOI]
  13. 13 Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats [DOI]
  14. 14 Cardioprotective Effect of Cucumis trigonus Roxb on Isoproterenol-Induced Myocardial Infarction in Rat [DOI]
  15. 15 Simvastatin and vitamin E effects on cardiac and hepatic oxidative stress in rats fed on high fat diet [DOI]
  16. 16 Preventive effects of p-coumaric acid on cardiac hypertrophy and alterations in electrocardiogram, lipids, and lipoproteins in experimentally induced myocardial infarcted rats [DOI]
  17. 17 Lipids, Lipoproteins, and Cardiovascular Disease: Clinical Pharmacology Now and in the Future [DOI]
  18. 18 Antihypertensive potential of the aqueous extract which combine leaf of Persea americana Mill. (Lauraceae), stems and leaf of Cymbopogon citratus (D.C) Stapf. (Poaceae), fruits of Citrus medical L. (Rutaceae) as well as honey in ethanol and sucrose experimental model [DOI]
  19. 19 In vitro and in vivo antidiabetic effect of extracts of Melia azedarach, Zanthoxylum alatum , and Tanacetum nubigenum [DOI]
  20. 20 Antihypertensive and antidiabetic activities of Erythrina senegalensis DC (Fabaceae) stem bark aqueous extract on diabetic hypertensive rats [DOI]
  21. 21 Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart [DOI]
  22. 22 Predictive model for atrial fibrillation in hypertensive diabetic patients [DOI]
  23. 23 An Altered Pattern of Myocardial Histopathological and Molecular Changes Underlies the Different Characteristics of Type-1 and Type-2 Diabetic Cardiac Dysfunction [DOI]
  24. 24 Effect of combined dyslipidemia and hyperglycemia on diabetic peripheral neuropathy in alloxan-induced diabetic WBN/Kob rats [DOI]
  25. 25 Cola nitida infusion modulates cardiometabolic activities linked to cardiomyopathy in diabetic rats [DOI]
  26. 26 E.C.G. findings in normal rats and after administration of isoproterenol.
  27. 27 Diabetes mellitus aggravates ranolazine-induced ECG changes in rats [DOI]
  28. 28 Increased capillary permeability to albumin in diabetic rat myocardium. [DOI]
  29. 29 Dysrhythmia and electrocardiographic changes in diabetes mellitus: pathophysiology and impact on the incidence of sudden cardiac death [DOI]
  30. 30 Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats [DOI]
  31. 31 Therapeutic activity of sarpogrelate and dopamine D2 receptor agonists on cardiovascular and renal systems in rats with alloxan-induced diabetes [DOI]
  32. 32 UNANI FORMULATIONS FOR MANAGEMENT OF DIABETES: AN OVERVIEW [DOI]
  33. 33 Arquivos Brasileiros de Cardiologia [DOI]
  34. 34 European Journal of Clinical Investigation [DOI]
  35. 35 International Journal of Green Pharmacy [DOI]
  36. 36 Journal of the American Heart Association [DOI]

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