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Research Article Open access CC BY 4.0

Epidemiology of Hepatitis C Virus Infection in Egypt

Fatma A. Amer, Maha Gohar, Monkez Yousef

International Journal of TROPICAL DISEASE & Health · pp. 119–131 · Published 15 Apr 2015

10.9734/IJTDH/2015/15727

Abstract

Hepatitis C virus constitutes an epidemic in Egypt having the highest prevalence in the world of 14.7%. The reasons behind this unique epidemic may be dated back to iatrogenic role of parenteral antischistosomal therapy campaigns to control endemic schistosomiasis. Other routes of infection are contributing to the ongoing HCV transmission. The prevalent genotype in Egypt is type 4 (73%), the origin, evolution, and dynamics are difficult to determine. Risk factors for acquiring HCV infection include: History of antischistosomal injection treatment before 1986, old age, male gender, and residence in rural areas. Other risk factors include; injection therapy, blood transfusion prior to 1994, exposure to various facility-based medical procedures, and occupational transmission among health care workers. In community settings, a set of risk factors, mostly related to prevailing social and cultural conditions, are responsible for maintaining the high rates of HCV transmission. Chronic HCV is the main cause of liver cirrhosis and liver cancer in Egypt and, indeed, one of the top five leading causes of death. It kills an estimated 40,000 Egyptians a year. When talking about children, current HCV seroprevalenceis high, approximately 5-8%. It is to be emphasized that HCV infection is not always benign in the childhood period in Egypt. It has been shown that blood transfusion, surgical procedures, dental treatment, male circumcision and age above 10 years are important risk factors associated with anti-HCV antibody prevalence. In addition, vertical transmissions, and household transmission have been documented as routes of transmission. Occult HCV infection is defined as elevated liver function tests and negative HCV antibodies in serum, while HCV RNA is detectable in liver tissue and peripheral polymorphonuclear cells (PBMCs). Interest in occult HCV has emerged recently in Egypt. Studies at a national level are being carried out, but no results have yet been released. Many small scale studies have been performed among particular patient groups, which have highlighted the importance of this disease entity.

HCV Egypt risk factors schistosomiasis pediatric HCV blood transfusion occupational hazards infection control traditions

References (71)

  1. 1 Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region [DOI]
  2. 2 Genetic diversity and evolution of hepatitis C virus – 15 years on [DOI]
  3. 3 Hepatitis C genotype 4 [DOI]
  4. 4 Hepatitis C Virus Infection in A Community in the Nile Delta: Risk Factors for Seropositivity [DOI]
  5. 5 Occult Hepatitis C Virus Infection in Patients in Whom the Etiology of Persistently Abnormal Results of Liver‐Function Tests Is Unknown [DOI]
  6. 6 The origin of hepatitis C virus genotypes. [DOI]
  7. 7 Occupational exposure to needlestick injuries and hepatitis B vaccination coverage among health care workers in Egypt [DOI]
  8. 8 The Epidemiology and Iatrogenic Transmission of Hepatitis C Virus in Egypt: A Bayesian Coalescent Approach [DOI]
  9. 9 Epidemiology of HIV infection in the Middle East and North Africa [DOI]
  10. 10 An updated analysis of hepatitis C virus genotypes and subtypes based on the complete coding region [DOI]
  11. 11 Changing pattern of hepatitis C virus spread in rural areas of Egypt [DOI]
  12. 12 Estimates of injecting drug users at the national and local level in developing and transitional countries, and gender and age distribution [DOI]
  13. 13 Intrafamilial Transmission of Hepatitis C in Egypt * [DOI]
  14. 14 Clinical, virological and histopathological features: long‐term follow‐up in patients with chronic hepatitis C co‐infected with S. mansoni [DOI]
  15. 15 Occult hepatitis C: How convincing are the current data? # [DOI]
  16. 16 Exponential Spread of Hepatitis C Virus Genotype 4a in Egypt [DOI]
  17. 17 High prevalence of hepatitis C virus among urban and rural population groups in Egypt [DOI]
  18. 18 Cellular Immune Responses in Seronegative Sexual Contacts of Acute Hepatitis C Patients [DOI]
  19. 19 Prospective cohort study of mother‐to‐infant infection and clearance of hepatitis C in rural Egyptian villages [DOI]
  20. 20 Prevalence of and risk factors for hepatitis C in rural pregnant Egyptian women [DOI]
  21. 21 Is the hepatitis C virus epidemic over in Egypt? Incidence and risk factors of new hepatitis C virus infections [DOI]
  22. 22 The hepatitis C virus epidemic in Cameroon: Genetic evidence for rapid transmission between 1920 and 1960 [DOI]
  23. 23 Spectrum of viral hepatitis in thalassemic children receiving multiple blood transfusions.
  24. 24 Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt [DOI]
  25. 25 Pattern of hepatitis virus infection among pregnant women and their newborns at the Women's Health Center of Assiut University, Upper Egypt [DOI]
  26. 26 Prevalence and risk factors of asymptomatic hepatitis C virus infection in Egyptian children [DOI]
  27. 27 Towards realistic estimates of HCV incidence in E gypt [DOI]
  28. 28 Risk factors for hepatitis C virus infection among Egyptian healthcare workers in a national liver diseases referral centre [DOI]
  29. 29 Hepatitis C virus infection among healthy Egyptian children: prevalence and risk factors [DOI]
  30. 30 TRANSMISSION OF HEPATITIS C VIRUS BETWEEN PARENTS AND CHILDREN [DOI]
  31. 31 Hepatitis C virus infection among paediatric patients attending University of Assiut Hospital, Egypt [DOI]
  32. 32 Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study [DOI]
  33. 33 Changing epidemiologic pattern of chronic hepatitis C virus infection in Italian children [DOI]
  34. 34 Changing Patterns of Acute Viral Hepatitis at a Major Urban Referral Center in Egypt [DOI]
  35. 35 Molecular Epidemiology of Hepatitis C Virus Genotype 4 Isolates in Egypt and Analysis of the Variability of Envelope Proteins E1 and E2 in Patients with Chronic Hepatitis [DOI]
  36. 36 Prevalence of Occult Hepatitis C Virus in Egyptian Patients with Chronic Lymphoproliferative Disorders [DOI]
  37. 37 Evaluation of an Isolation Program of Hepatitis C Virus Infected Hemodialysis Patients in Some Hemodialysis Centers in Egypt [DOI]
  38. 38 Hepatitis G virus infection in Egyptian children with chronic renal failure (single centre study) [DOI]
  39. 39 Prevalence of occult hepatitis C in egyptian patients with non alcoholic fatty liver disease [DOI]
  40. 40 Anti-HCV Prevalence among Diabetic and Non-Diabetic Egyptian Children [DOI]
  41. 41 Intrafamilial Transmission of Hepatitis C Virus Infection [DOI]
  42. 42 Brief report. Prevalence of hepatitis C virus (HCV) infection and its vertical transmission in Egyptian pregnant women and their newborns [DOI]
  43. 43 Transplacental transmission of hepatitis C virus in HIV-negative mother [DOI]
  44. 44 Genotypes and subtypes of hepatitis C virus in Burundi: a particularity in Sub-saharan Africa [DOI]
  45. 45 Hepatitis C virus transmission in family members of Egyptian patients with HCV related chronic liver disease.
  46. 46 Distinct immunoregulatory cytokine pattern in Egyptian patients with occult Hepatitis C infection and unexplained persistently elevated liver transaminases [DOI]
  47. 47 Transfusion Transmitted Virus (TTV) Infection in Polytransfused Egyptian Thalassemic Children [DOI]
  48. 48 Hepatitis C and B Viruses Among Some High Risk Groups of Egyptian Children [DOI]
  49. 49 Hepatitis C virus infection in Egyptian children with type 1 diabetes mellitus: A single center study [DOI]
  50. 50 Prevalence of hepatitis C virus among non-A, non-B-related chronic liver disease in Egypt [DOI]
  51. 51 Epidemiology of hepatitis C virus infection [DOI]
  52. 52 Global challenges in liver disease [DOI]
  53. 53 The epidemiology of hepatitis C virus in Egypt: a systematic review and data synthesis [DOI]
  54. 54 Genetic Epidemiology of Hepatitis C Virus throughout Egypt [DOI]
  55. 55 Global estimates of prevalence of HCV infection among injecting drug users [DOI]
  56. 56 Hepatitis C virus (HCV) infection in a community in the nile delta: Population description and HCV prevalence [DOI]
  57. 57 Evidence of intense ongoing endemic transmission of hepatitis C virus in Egypt [DOI]
  58. 58 Hepatitis c in a community in Upper Egypt: risk factors for infection. [DOI]
  59. 59 Chronic liver disease in the Alexandria governorate, Egypt: contribution of schistosomiasis and hepatitis virus infections [DOI]
  60. 60 High HCV prevalence in Egyptian blood donors [DOI]
  61. 61 Phylogenetic analysis of hepatitis C virus isolates indicates a unique pattern of endemic infection in Cameroon [DOI]
  62. 62 Estimation of the risk of transmission of hepatitis C between spouses in Egypt based on seroprevalence data [DOI]
  63. 63 Prospective Study of Prevalence and Risk Factors for Hepatitis C in Pregnant Egyptian Women and Its Transmission to Their Infants [DOI]
  64. 64 Risk Factors of Hepatitis C Infection among Egyptian Blood Donors [DOI]
  65. 65 Methods of transmission of hepatitis C [DOI]
  66. 66 Hepatitis C virus genotyping in relation to neu-oncoprotein overexpression and the development of hepatocellular carcinoma [DOI]
  67. 67 Hepatitis C virus infection in blood donors in Egypt.
  68. 68 An Egyptian Study of Mother to Child Transmission of Hepatitis C Virus [DOI]
  69. 69 Prevalence of Hepatitis-C Antibody Seropositivity in Healthy Egyptian Children and Four High Risk Groups [DOI]
  70. 70 Informal health providers and the transmission of hepatitis C virus: pilot study in two Egyptian villages.
  71. 71 Intravenous drug addicts: a high risk group for infection with human immunodeficiency virus, hepatitis viruses, cytomegalo virus and bacterial infections in Alexandria Egypt.

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