Erythropoietic Effects of Eremomastax polysperma Leaf Extracts on Female Prepubertal and Pubertal Wistar Rats
O. E. Mboso, M. O. Odey, F. E. Uboh, N. M. Essien, O. Chidinma, E. U. Eyong
Journal of Pharmaceutical Research International · pp. 1833–1839 · Published 27 Jul 2014
10.9734/BJPR/2014/9603Abstract
This study assessed the erythropoietic effect of Eremomastax polysperma leaf extracts in female albino Wistar rats. Method: Twenty eight (28) female rats were divided into two major groups based on their weight and age. The duration of administration of E. polysperma extracts lasted for twenty one (21) days. This study was carried out in the Department of Biochemistry University of Calabar, between February and March 2013. A significant increase (P<0.05) in red blood cell count (RBC) (8.17±0.48, 6.46±0.37) and Haemoglobin (Hb) count (15.13±1.03, 13.27±0.7) was observed in the prepubertal group compared to the control, while packed cell volume (PCV) was significantly increased (P<0.05) in the pubertal group compared to the control (55.40±4.40, 48.63±2.33 respectively). This suggests that E. polysperma leaf extract can be used as a haematinic and a therapy for anaemic conditions.
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