Estimating the Diagnostic Accuracy of High Sensitive C- Reactive Protein (hs-CRP) in Early Detection of Neonatal Sepsis

Abstract

Background:  Neonatal sepsis is a critical issue and if sepsis in neonates is diagnosed early by reliable tests, we can avoid unwanted administration of higher antibiotics, reduce the expenses of hospital care and also prevent emergence of bacterial strains that are resistance to antibiotics. Detecting neonatal sepsis in its earlier stage is still difficult as it presents as a variety of symptoms that could also classify many other disorders. Early onset sepsis presents within 72 hours of birth.  This study aims to measure the efficacy of high sensitive CRP (hs-CRP) in early diagnosis of neonatal sepsis. Methodology: This prospective cross sectional study will be conducted at AVBRH, Wardha. Two serial measurements of hs-CRP will be taken and values will be correlated with respect to other conventional screening markers.  CRP and hs-CRP levels in these populations will be studied and compared to assess sensitivity, specificity and observed cut off values for the same. The neonates will be followed up during hospital stay till discharge and outcome will be noted and all data will be collected. Data analysis will be done at the end using appropriate statistical methods. Expected Results: In our study we expect hs-CRP to be more sensitive in predicting neonatal sepsis as compared to conventional markers like CRP, Septic screen. We expect hs-CRP to be a better predictor in diagnosing sepsis so that we can intervene early and reduce morbidity and hospital stay. Conclusion: Inclusion of hs-CRP as part of routine screening of neonates for sepsis can be recommended.