Evaluating Toxicity Profile of Garlic (Allium sativum) on the Liver, Kidney and Heart Using Wistar Rat Model
A. A. Fowotade, A. Fowotade, B. U. Enaibe, G. O. Avwioro
International Journal of TROPICAL DISEASE & Health · pp. 1–12 · Published 6 Oct 2017
10.9734/IJTDH/2017/36282Abstract
Background: The medicinal values of Allium sativum has been extensively described in a number of studies. Additionally, it has shown antimicrobial activity against a wide spectrum of microorganism; bacteria, fungi and parasites. The widespread benefit of garlic for its medicinal properties has resulted in its increased usage thus justifying the need to study the potential toxicity of garlic extracts on vital organs of the body. The present study aims to evaluate the toxicity profile of garlic extract in Wistar rats. Materials and Methods: Thirty five male rats of Wistar strains were randomly grouped into seven (A-G) of five animals each. Animals in the control group received 1ml of physiological saline intraperitoneally for 38 days. Group A (5 mice) were given 250 mg/kg of garlic extract daily. Group B (5 mice) received 300 mg/kg of garlic extract daily, Group C (5 mice) received 350 mg/kg of garlic extract daily, Group D (5 mice) received 400 mg/kg of garlic extract daily. Group E (5 mice) received 450 mg/kg of garlic extract daily. Group F (5 mice) received 500 mg/kg of garlic extract daily. All administration were done intraperitoneally for 38 days following which blood specimens were collected for biochemical analysis and the animals sacrificed for histological analysis. Results: The result of the study showed a dose dependent increase in levels of liver enzymes 9AST, ALT and ALP) as well as an increase in serum creatinine levels. Additional findings included dose dependent histologic alterations in hepatic, renal and cardiac functions compared with the control group 6. Conclusion: This study therefore highlights the safety of garlic at low levels and the potential toxicity of high dose garlic extract to the liver, heart and kidney.
References (18)
- 1 Medicinal plants and traditional medicine in Africa
- 2 A SIMPLIFIED METHOD FOR THE ESTIMATION OF TOTAL CHOLESTEROL IN SERUM AND DEMONSTRATION OF ITS SPECIFICITY [DOI]
- 3 Clinical Guide to Laboratory Tests. [DOI]
- 4 Garlic and Cardiovascular Disease: A Critical Review [DOI]
- 5 Health effects of garlic.
- 6 Effects of garlic on platelet biochemistry and physiology [DOI]
- 7 Determination of Serum Calcium by Means of Orthocresolphthalein Complexone [DOI]
- 8 Effects of Garlic on Lipid Metabolism in Rats Fed Cholesterol or Lard [DOI]
- 9 Dose-dependent induction of endogenous antioxidants in rat heart by chronic administration of garlic [DOI]
- 10 Sublethal effects of an organophosphorus insecticide (RPR-II) on biochemical parameters of tilapia, Oreochromis mossambicus [DOI]
- 11 Including Garlic in the Diet May Help Lower Blood Glucose, Cholesterol, and Triglycerides [DOI]
- 12 Antimicrobial activity of garlic against oral streptococci [DOI]
- 13 Synthesis and neuropharmacological activity of some quinoxalinone derivatives
- 14 Phytochemical screening, elemental analysis and acute toxicity of aqueous extract of Allium sativum L. bulbs in experimental rabbits [DOI]
- 15 Hypocholesteremic and Antioxidant Effects of Garlic (Allium sativum L.) Extract in Rats Fed High Cholesterol Diet [DOI]
- 16 Amelioration of lead-induced hepatotoxicity byAllium sativumextracts in Swiss albino mice [DOI]
- 17 Histopathological effects of garlic on liver and lung of rats [DOI]
- 18 [Pharmaceutical importance of Allium sativum L. 5. Hypolipemic effects in vitro and in vivo].
Cited by 31
Hafidz Abdullah, Isnatin Miladiyah · Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021) · 2022
Ashraful Alam, Abdullah Al Arif Jahan, Md. Sazzadul Bari · Critical Reviews in Food Science and Nutrition · 2022
Obeta M. Uchejeso, Ikeagwulonu R. Chinaza, Ohanube A.K. Goodluck · Alternative Medicine - Update · 2021
Donisha Shani Niharika Keembiya Liyanagamage, Susanthi Jayasinghe, Anoja Priyadarshani Attanayake · Evidence-Based Complementary and Alternative Medicine · 2020
Ivan A. Ross · Plant-Based Therapeutics, Volume 3 · 2025
Zeinab Kamal, Zeinab Al-Amgad, František Zigo · Journal of Applied Animal Research · 2023
Janelly Burgos-Pino, Brandon Gual-Orozco, Marina Vera-Ku · Journal of Ethnopharmacology · 2023
Xing-Yang Zhu, Yi-Rong Zeng · Journal of International Medical Research · 2020
Hala A. Farrag, Alaa El-Dien M.S. Hosny, Asrar M. Hawas · Saudi Pharmaceutical Journal · 2019
Oluwadunni Okwulu, Ibrahim Lawal, Onakpa Micheal · 2024
Showing 12 of 31 known citations — external sources report more than can currently be individually listed.
Related research
- Effect of Pearl Millet on Glycaemic Control and Lipid Profile in Streptozocin Induced Diabetic Wistar Rat Model — shares topic coverage
- Effect of Beet Root (Beta vulgaris), White and Red Radish (Raphanus sativus and Raphanus longipinnatus) Juice Extract, on Salt Induced Hypertensive Wistar Rats — shares topic coverage
- Effect of Palm Kernel Oil on Plasma Sodium, Potassium and Chloride in Wistar Rats Induced with Febrile Seizures — shares topic coverage
- Effects of Nigella sativa Linn. Oil on Gut Bacteria and Liver Function Status of Albino Wistar Rats — shares topic coverage
- Effect of Garcinia Kola Consumption on Lipid Profile and Body Weight of Rats Fed with High Fat Diet — shares topic coverage
Article metrics
Real usage data collected on this platform.
16
Page views
0
PDF downloads
2
Outbound clicks
31
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.