Evaluation of the Ex vivo and In vitro Antidiabetic and Antioxidant Activities of the Hydroalcoholic Extract of Psidium guajava L. Leaves (Myrtaceae)
Afangbom Kossi, Motto Aku Enam, MELILA Mamatchi, Atchou Kokou, Lawson-EVI Povi
Asian Journal of Biology · pp. 67–76 · Published 22 May 2024
10.9734/ajob/2024/v20i6416Abstract
Objective: Antidiabetic activity was assessed by the skeletal muscle glucose uptake test and antioxidant potential by the total antioxidant capacity, reducing power and DPPH test. Materials and Methods: Same-sex Sprague Dawley rats weighing 150±20 g and approximately 3 months old and different concentrations of the extract obtained from 500 g of P. guajava leaves powder were used for the following methods: reduction, free radical scavenging, glucose uptake by skeletal muscle. Results: In terms of antioxidant potential, the extract showed significant activity in a dose-dependent manner. In addition, the extract potentiated glucose uptake in the presence and absence of insulin. Compared with metformin and glibenclamide, the extract increased glucose uptake to a greater extent. Conclusion: This study shows that the hydroethanolic extract of guava leaves is one of the best recipes for helping to delay the complications associated with diabetes.
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