Formulation and Evaluation of Captopril Mouth Dissolving Film
V. T. Iswariya, P. Deepika, Sowjanya Battu
Current Journal of Applied Science and Technology · pp. 54–60 · Published 5 Jul 2021
10.9734/cjast/2021/v40i1531414Abstract
The goal of this research is to develop captopril mouth dissolving films and evaluate the impact of various formulation factors on the physical and mechanical properties of the films, as well as drug release behaviour. In different grades, hydroxypropyl methyl cellulose (HPMC E15 and K4M) was employed as the film forming polymer. Formulation disintegration times were determined to be in the range of (52 2.5 to 125.6 2.02 s). Formula F2 had the fastest disintegration time in vitro (52 2.5 s) and was determined to be acceptable for film production with ideal physicochemical qualities, faster disintegration, and optimal in vitro release. It may be concluded that the solvent casting approach can be used to make captopril mouth dissolving films with a higher dissolution rate and greater patient compliance.
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