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Research Article Open access CC BY 4.0

Formulation and Evaluation Thermoreversible Gel of Antifungal Agent for Treatment of Vaginal Infection

Manisha V. Patil, Rahul L. Jadhav, Siraj N. Shaikh, Santosh N. Belhekar

Journal of Pharmaceutical Research International · pp. 58–66 · Published 12 Mar 2020

10.9734/jpri/2020/v32i230404

Abstract

Aims: The aim this research work is to formulate and evaluate thermoreversible gel of antifungal agent Clotrimazole for treatment of vaginal infection. Place and Duration of Study: Department of Biopharmaceutics, Government College of Pharmacy, Karad, Maharashtra, India, between June 2009 and July 2010. Methodology: Different Formulations of thermoreversible gel of antifungal agent Clotrimazole were prepared by using various concentrations of ethanol, PEG 400, sodium dodecyl sulphate, polycarbophil and pluronic F 127 and pluronic F 68. The gel formulations were subjected for evaluation on the basis of rheological behaviour, mucoadhesive behaviour, in-vitro performance. Results: The results indicate that Polymers such as polycarbophil, PEG- 400 in various concentrations to prepare formulations were found to release drug for period over 12 hrs. Without getting dislodged. The formulations have satisfactory rheological behavior and their diffusion profile is comparable to the marketed gel formulation. Significant difference was observed in the rheological behavior of formulations. Gel strength, spreadability, mucoadhesive strength of formulation B and C were desirable. Drug diffusion of formulation B and C were 95.2% release after 11 hrs 98.5% release after 11 hrs, respectively which was good as compared to marketed formulation showing drug diffusion of 102.2% after 10 hrs. Conclusion: On basis of the results we concluded that developed thermoreversible gel of Clotrimazole will be better alternative to conventional dosage form Clotrimazole & will improve patient compliance.

Antifungal pluronic F-127 clotrimazole thermoreversible gel vaginal infection spreadability.

References (10)

  1. 1 The vagina as a route for systemic drug delivery [DOI]
  2. 2 Applications of thermo-reversible pluronic F-127 gels in pharmaceutical formulations.
  3. 3 Gels as vaginal drug delivery systems [DOI]
  4. 4 Rheological evaluation of thermosensitive and mucoadhesive vaginal gels in physiological conditions [DOI]
  5. 5 Drug release from pluronic F-127 gels /
  6. 6 DEVELOPMENT OF IN SITU GELLING AND MUCOADHESIVE MEBEVERINE HYDROCHLORIDE SOLUTION FOR RECTAL ADMINISTRATION
  7. 7 Formulation And Evaluation of Topical Aceclofenac Gel UsingDifferent Gelling Agent
  8. 8 A Study on Superficial Fungal Infection from West Bengal: A Brief Report [DOI]
  9. 9 GELLIFIED EMULSION FOR SUSTAIN DELIVERY OF ITRACONAZOLE FOR TOPICAL FUNGAL DISEASES
  10. 10 Effect of gel composition and phonophoresis on the transdermal delivery of ibuprofen: In vitro and in vivo evaluation [DOI]

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