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Research Article Open access CC BY 3.0

Formulation and In vitro Evaluation of Fluconazole Topical Gels

Aml Mekkawy, M. Fathy, Sohair El-Shanawany

Journal of Pharmaceutical Research International · pp. 293–313 · Published 11 Mar 2013

10.9734/BJPR/2013/2775

Abstract

Aims: Topical drug delivery of fluconazole, an antifungal drug, in gel form was formulated to avoid the side effect of the oral route. Study Design: In this study I prepare different formulation from different polymers and select the best formulation to undergo further antifungal and stability studies. Place and Duration of Study: Faculty of Pharmacy, Department of Pharmaceutics, Assiut University, between May 2010 and July 2011. Methodology: Different polymers; Sodium carboxymethyl cellulose, Sodium alginate, Carbopol 934P, Hydroxypropylmethyl cellulose, Pluronic F-127 and hydroxypropyl cellulose, were used. The compatibility of fluconazole and different gelling polymer was assessed through differential scanning calorimetry and infrared absorption spectroscopy. The influence of polymer type and concentration on fluconazole release from the prepared gels were studied. The prepared gel formulations were evaluated for pH, drug content, rheology, spreadability and in vitro drug release Results: The rheological behavior of all the prepared gels showed a pseudoplastic flow (shear thinning) which is a good characteristic in the pharmaceutical gels. With the increase of the polymer concentration in the formulation, viscosity increased and in vitro release of fluconazole decreased. Among all the prepared formulations, 0.5% Carbopol 934P gel showed desired properties and exhibited the best fluconazole in vitro release that reaches 77% over a 3-hr period. This gel showed a good inhibition to the fungal growth against Candida albicans and Trichophyton mentagrophyte using cup plate method and also, showed good stability. Conclusion: 0.5% Carbopol 934P / Fluconazole gel is a promising dosage form for the treatment of superficial fungal infections and could be used for further clinical studies.

Fluconazole solubility hydrogels polymers calorimetry (DSC) rheology in vitro release kinetics antifungal activity.

References (27)

  1. 1 Artificial skin I. Preparation and properties of pluronic F‐127 gels for treatment of burns [DOI]
  2. 2 Topical delivery of antifungal agents [DOI]
  3. 3 Experimental investigation and mathematical modeling of Pluronic® F127 gel dissolution: drug release in stirred systems [DOI]
  4. 4 Controlled-Release Delivery System for the α-MSH Analog Melanotan-I Using Poloxamer 407 [DOI]
  5. 5 The development of Cutina lipogels and gel microemulsion for topical administration of fluconazole [DOI]
  6. 6 In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels [DOI]
  7. 7 Controlled release and dura mater permeability of lidocaine and ibuprofen from injectable poloxamer-based gels [DOI]
  8. 8 In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives [DOI]
  9. 9 Relationship Between Polymer Viscosity and Drug Release from a Matrix System [DOI]
  10. 10 The effect of rheological behaviour of a topical anaesthetic formulation on the release and permeation rates of the active compound [DOI]
  11. 11 Formulation And Evaluation of Topical Aceclofenac Gel UsingDifferent Gelling Agent
  12. 12 Topical Permeation Characteristics of Diclofenac Sodium from NaCMC Gels in Comparison with Conventional Gel Formulations [DOI]
  13. 13 A General Overview on Past, Present and Future Antimycotics~!2009-11-01~!2010-04-06~!2010-06-24~! [DOI]
  14. 14 A Study on Superficial Fungal Infection from West Bengal: A Brief Report [DOI]
  15. 15 Theory of Diffusion in Gels [DOI]
  16. 16 The Alginate Demonstration: Polymers, Food Science, and Ion Exchange [DOI]
  17. 17 In Vitro Release Studies of Flurbiprofen from Different Topical Formulations [DOI]
  18. 18 GELLIFIED EMULSION FOR SUSTAIN DELIVERY OF ITRACONAZOLE FOR TOPICAL FUNGAL DISEASES
  19. 19 Formulation and evaluation of clotrimazole from pluronic F127 gels.
  20. 20 Atlas of fungal infections
  21. 21 In vitro release of lidocaine from pluronic F-127 gels [DOI]
  22. 22 Permeation of Piroxicam from the Poloxamer Gels [DOI]
  23. 23 Effect of gel composition and phonophoresis on the transdermal delivery of ibuprofen: In vitro and in vivo evaluation [DOI]
  24. 24 Trends in the treatment of dermatophytosis.
  25. 25 In Vitro Studies Of Mucoadhesiveness And Release Of Nicotinamide Oral Gels Prepared From Bioadhesive Polymers [DOI]
  26. 26 Release of Tolmetin from Carbomw Gel Systems [DOI]
  27. 27 In vitro release characteristics of diclofenac and hydrocortisone from Pluronic F-127 gels.

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