Gene Expression Endpoints Following Subchronic Thiamethoxam Exposure in Adult Male Rabbits
Ahmed R. Elsawasany, Alexander A. Deltsov, Osama S. El Okle, Omnia I. El Euony, Sergey V. Pozyabin, Konstantin S. Ostrenko
Annual Research & Review in Biology · pp. 1–9 · Published 2 Apr 2022
10.9734/arrb/2022/v37i330492Abstract
Aim: to investigate the sub chronic toxicity of thiamethoxam on some parameters of reproductive performance in adult male rabbits including gene expression of LDH-C4, FSHβ and LHβ and GnRHR. Method: sixteen adult male Chinchilla rabbits were divided into two equal groups. Animals in the first group were treated orally with TMX at dose of 250 mg/kg body weight for 90 days. The second group was served as control. Result: Obtained results showed that TMX increased the relative weight of some reproductive organs including testis and prostate. Hormonal analysis revealed that, TMX induced a significant elevation in the serum testosterone level, while the concentrations of FSH and LH hormones did not exhibit any alterations between treated and control groups. In addition, LDH-C4, FSHβ and LHβ and GnRHR genes were down regulated in TMX treated group. Conclusion: Administration of thiamethoxam for 90 days in male rabbits induced a noticeable adverse effect on serum testosterone level and down regulated genes related to male rabbit reproductive performance.
References (31)
- 1 Statistical analysis of real-time PCR data [DOI]
- 2 NEONICOTINOID INSECTICIDE TOXICOLOGY: Mechanisms of Selective Action [DOI]
- 3 Nitric oxide synthase: Aspects concerning structure and catalysis [DOI]
- 4 Farm Chemicals Handbook [DOI]
- 5 Mechanism of Neonicotinoid Toxicity: Impact on Oxidative Stress and Metabolism [DOI]
- 6 Expression of the Gene for Mouse Lactate Dehydrogenase C (Ldhc) Is Required for Male Fertility1 [DOI]
- 7 Unique and Common Metabolites of Thiamethoxam, Clothianidin, and Dinotefuran in Mice [DOI]
- 8 Acute Human Self-Poisoning with Imidacloprid Compound: A Neonicotinoid Insecticide [DOI]
- 9 Insecticide imidacloprid induces morphological and DNA damage through oxidative toxicity on the reproductive organs of developing male rats [DOI]
- 10 Hormones in synergy: Regulation of the pituitary gonadotropin genes [DOI]
- 11 Neurotoxic Effects of Neonicotinoids on Mammals: What Is There beyond the Activation of Nicotinic Acetylcholine Receptors?—A Systematic Review [DOI]
- 12 Assessment of imidacloprid toxicity on reproductive organ system of adult male rats [DOI]
- 13 Two cases of acute poisoning with acetamiprid in humans [DOI]
- 14 Hypothalamic Control of the Pituitary‐Gonadal Axis in Higher Primates: Key Advances over the Last Two Decades [DOI]
- 15 Imidacloprid Impacts on Neurobehavioral Performance, Oxidative Stress, and Apoptotic Events in the Brain of Adolescent and Adult Rats [DOI]
- 16 Effects of low-level imidacloprid oral exposure on cholinesterase activity, oxidative stress responses, and primary DNA damage in the blood and brain of male Wistar rats [DOI]
- 17 Protection of Testicular Dysfunctions by MTEC, a Formulated Herbal Drug, in Streptozotocin Induced Diabetic Rat [DOI]
- 18 Regulation of reproduction via tight control of gonadotropin hormone levels [DOI]
- 19 Gonadotropin-releasing hormone neurons Intrinsic pulsatility and receptor-mediated regulation [DOI]
- 20 Acetamiprid Accumulates in Different Amounts in Murine Brain Regions [DOI]
- 21 Effects of the neonicotinoid insecticide, clothianidin, on the reproductive organ system in adult male rats [DOI]
- 22 Neonicotinoid formaldehyde generators: Possible mechanism of mouse-specific hepatotoxicity/hepatocarcinogenicity of thiamethoxam [DOI]
- 23 Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin [DOI]
- 24 Nicotinic Cholinergic System in the Hypothalamus Modulates the Activity of the Hypothalamic Neuropeptides During the Stress Response [DOI]
- 25 Toxicology of the newer neonicotinoid insecticides: Imidacloprid poisoning in a human [DOI]
- 26 Reproductive implications of LDH-C4 and other testis-specific isozymes.
- 27 Gonadotropin-releasing hormone receptors: structure and signal transduction pathways [DOI]
- 28 A toxicokinetic model for thiamethoxam in rats: implications for higher-tier risk assessment [DOI]
- 29 Effects of GnRH agonist on reproductive functions of female rabbits
- 30 Lactate Dehydrogenases: Structure and Function [DOI]
- 31 Lactate Dehydrogenase-C4 (LDH-C4) Is Essential for Sperm Function. [DOI]
Cited by 0
No indexed citations yet.
Related research
- Assessing the Impact of Onion Juice on the Levels of Leutinizing Hormone and Follicle Stimulating Hormone in Female Mice Exposed to Transfluthrin Smoke — shares topic coverage
- LH/FSH, BMI and Clinical Profile in Polycystic Ovarian Syndrome: A Correlative Study — shares topic coverage
- Assessment of Ovarian Integrity, Reproductive Hormones, and Oxidative Stress in Albino Rats Exposed to Tartrazine Azo Dye — shares topic coverage
- Evaluation of Fertility Hormones in Type 2 Diabetic Male Subjects in Nauth, Nnewi — shares topic coverage
- The Impact of Zinc Oxide Nanoparticle on LH, FSH, and Testosterone Hormones in Mature Male NMRI Rats — shares topic coverage
Article metrics
Real usage data collected on this platform.
65
Page views
0
PDF downloads
12
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.