Hepatoprotective Investigation of Ficus lyrataand Ficus elastic Leaves Extract
Mrinal Aryan, Ashish Manigauha, Vishal Gupta
Journal of Pharmaceutical Research International · pp. 130–138 · Published 21 Oct 2024
10.9734/jpri/2024/v36i117606Abstract
In hepatotoxic Albino rats caused by isoniazid and paracetamol, the hydroalcoholic extract of Ficus lyrata and Ficus elastic leaves was evaluated for hepatoprotective activity. The degree of protection was measured by estimating biochemical parameters such as serum glutamate Oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), ALP and the level of total serum bilirubin. In rats that had been toxicated with isoniazid and paracetamol. Hydroalcoholic extract (100 mg/kg, 200 mg/kg) demonstrated a noteworthy hepatoprotective effect in a dose-dependent manner. The extract's hepatoprotective benefits were on par with those of the prescribed medication silymarin 2.5 mg/kg body weight.
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