Hepatotoxicity of Ethanol Extract of Adenium obesum Stem Bark in Wistar Rats
Samson Eneojo Abalaka, Muhammad Yakasai Fatihu, Najume Doguwar Giginya Ibrahim, Suleiman Folorunsho Ambali
Journal of Pharmaceutical Research International · pp. 1041–1052 · Published 20 Mar 2014
10.9734/BJPR/2014/7667Abstract
Aims: Adenium obesum is a known medicinal plant thereby creating the need for the evaluation of its toxicity and histopathological effects on the liver of female Wistar rats orally administered ethanol extract of the plant’s stem bark. Place and Duration of Study: Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria, between January 2011 and January 2012. Methodology: Ethanol extraction of A. obesum stem bark was performed prior to screening it for its phytochemical constituents. Female rats per group were orally administered by gavage pre-defined doses (300mgkg-1, 2000mgkg-1 and 5000 mgkg-1) of the extract separatively in a stepwise procedure and observed for signs of toxicity. Control rats were administered distilled water placebo. Results: The extract contained some alkaloids, saponins, tannins, flavonoids, glycosides, steroids and triterpens with no anthraquinones. Exposed rats did not show signs of toxicity and neither was there any mortality. Changes in aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities were non-significant (p>0.05). Congestion and fatty degenerative changes were seen in the liver of the exposed rats, which were not significantly (p>0.05) different in exposed rats compared to the control. Conclusion: Adenium obesum did not cause major hepatic damage in the exposed rats and therefore, it is a safe oral medicinal plant within the extract dose and exposure period used in the study.
References (32)
- 1 Mechanisms of Hepatotoxicity [DOI]
- 2 Phenolic Compounds and Antioxidant Capacity of Georgia-Grown Blueberries and Blackberries [DOI]
- 3 A CONVENIENT METHOD FOR DETERMINING SERUM AND BILE PHOSPHATASE ACTIVITY.
- 4 Medicinal plants: a re-emerging health aid [DOI]
- 5 Manual of Histological Techniques and Their Diagnostic Application
- 6 African traditional medicine A dictionary of plant use and applications
- 7 A 90-day oral gavage toxicity study of d-methylphenidate and d,l-methylphenidate in Sprague–Dawley rats [DOI]
- 8 A Brief Overview of Nonneoplastic Hepatic Toxicity in Fish [DOI]
- 9 Trees, shrubs, and lianas of West African dry zones
- 10 The Potential of African Plants as a Source of Drugs [DOI]
- 11 Drugs and the liver part 1: Testing liver function [DOI]
- 12 Fish gills as a monitor of sublethal and chronic effects of pollution
- 13 Modern phytomedicine: Turning Medicinal Plants into Drugs
- 14 The Structure and Function of Fish Liver [DOI]
- 15 [Drugs and the liver].
- 16 Biochemical, physiological, and histological changes in the neotropical fish Prochilodus lineatus exposed to diesel oil [DOI]
- 17 Herbal bioactivation, molecular targets and the toxicity relevance [DOI]
- 18 Poison Arrows: North American Indian Hunting and Warfare
- 19 Antiproliferative activity of selected medicinal plants of Jordan against a breast adenocarcinoma cell line (MCF7) [DOI]
- 20 The Role of Complementary and Alternative Medicine: Accommodating Pluralism [DOI]
- 21 Pharmacology and Phytochemistry of Pakistani Herbs and Herbal Drugs Used for Treatment of Diabetes [DOI]
- 22 Acute And Subchronic Toxicity Of Anacardium occidentale Linn (Anacardiaceae) Leaves Hexane Extract In Mice. [DOI]
- 23 In Vivo. andIn Vitro. Toxicity Study ofGracilaria changii. [DOI]
- 24 Evaluation of the Acute and Subchronic Toxicities of Ethanol Leaf Extract of Spathodea campanulata P. Beauv.
- 25 Chlorpyrifos-Induced Clinical, Hematological and Biochemical Changes in Swiss Albino Mice- Mitigating effect by co-administration of vitamins C and E
- 26 Synergistic Activity of Methanolic Extract of Adenium obesum (Apocynaceae) Stem-Bark and Oxytetracycline against Some Clinical Bacterial Isolates [DOI]
- 27 Effect of Long-term use of Sida rhombifolia L. Extract on Haemato-biochemical Parameters of Experimental Animals [DOI]
- 28 HEPATOPROTECTIVE ACTIVITY OF AEGLE MARRMELOS AGAINST ETHANOL INDUCED HEPATOTOXICITY IN RATS
- 29 International Federation of Clinical Chemistry, Education Committee and International Union of Pure and Applied Chemistry, Division of Clinical Chemistry: definition of the terms certification, licensure and accreditation in clinical chemistry.
- 30 Decreased activity of commonly measured serum enzymes: causes and clinical significance.
- 31 Serum Enzyme and Histological Studies of Albino Rat Treated with Ethanol/potash Extract of Sorghum bicolor Leaf Sheath
- 32 Evaluation of plants used for the control of animal ectoparasitoses in Southern Ethiopia (Oromiya and Somali regions)
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