Hypoglyceamic Effect of Methanolic Extract of Pergularia daemia in Alloxan-Induced Diabetic Mice
A. O. Sijuade, O. O. Omotayo, O. A. Oseni
Journal of Pharmaceutical Research International · pp. 2614–2621 · Published 19 Nov 2014
10.9734/BJPR/2014/13101Abstract
Objective: The aim of the present study was to investigate the antidiabetic potential of Pergularia daemiamethanolic extract (PD) on alloxan-induced diabetic mice. Methods: Diabetes was induced using alloxan (150mg/kg). Different doses of the methanolic extract of P. daemia were prepared and administered orally. The alloxan-induced diabetic mice were treated with 200, 400 and 1000 mg/kg body weight (b.w.) methanolic extract of Pergularia daemia and the blood glucose levels were measured over 4 hrs. Results: All doses of the extract (200, 400 and 1000 mg/kg b.w) significantly (p<0.0001) lowered fasting blood glucose level after treatment. The hypoglycaemic effect of the methanolic extract was also compared with that of an oral dose of glibenclamide under the same conditions. The extract showed significant (p<0.05) hypoglycemic effect in alloxan-induced diabetic mice. The glucose half-life (t1/2G) (p<0.0001), Mean Glucose Residence Time (MRTG) (p<0.0001), and the area under glucose concentration time curve (AUC0-4hG) (p<0.05) were high in control group compared to the alloxan-induced mice treated with P. daemia extract. Conclusion: The results of this study indicate that methanolic extract of the plant of Pegularia daemiapossess hypoglycaemic activity.
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Cited by 9
A. O. Sijuade, J. O. Fadare, O. A. Oseni · Journal of Advances in Medicine and Medical Research · 2016
M. B. Adinortey, Rosemary Agbeko, Daniel Boison · Evidence-Based Complementary and Alternative Medicine · 2019
Suresh Mickymaray, M. S. Al Aboody, P. Rath · 2016
A. Sijuade · 2016
Yasodha Krishna Janapti · 2015
Showing 5 of 9 known citations — external sources report more than can currently be individually listed.
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