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Research Article Open access CC BY 4.0

Implication of Some Energy Drink Mixture with Flunitrazepam on Endurance Pattern and Cognitive/Motor Functions in Wistar Rats

K. M. Odia, Blessing Ukoro

International Neuropsychiatric Disease Journal · pp. 54–60 · Published 26 Apr 2024

10.9734/indj/2024/v21i3435

Abstract

This study was conducted to investigate the effects of some energy drinks mixture with Flunitrazepam on endurance pattern and cognitomotor activities in male Wistar rats. 45 Wistar rats were divided into 8 groups. Group 1 received distilled water; Group 2 received energy drink (A) (3.75 mg/kg). Group 3 energy drink (A) (7.5 mg/kg) Group 4 received energy drink (B) (3.75 mg/kg). Group 5 energy drink (B) (7.5 mg/kg) Group 6 received flunitrazepam (0.03 ml/kg), Group 7 received 3.75 ml/kg of energy drink (A) and 0.03 ml/kg of flunitrazepam, and Group 8 received 3.75 ml/kg of energy drink (B) and 0.03 ml/kg of flunitrazepam. Administration of the mixture lasted for 28 days while endurance test/Cognitive and motor functions test were conducted weekly using Handgrip test, beam walk test and navigational maze test. The result reveals significant improvement in endurance pattern and cognitomotor functions in groups administered with energy drinks alone at week one, however the mixture of energy drink with various doses of Flunitrazepam showed significant impairment in both endurance pattern, and cognitomotor activities. It was therefore concluded that while the combination of energy drinks and flunitrazepam may offer short-term benefits in terms of endurance, and alertness, there is a dose and time dependent significant decline in cognitive and motor functions functions in wistar rats. The findings suggest significant variations in endurance and cognitive-motor performance across different groups, highlighting the complex interactions between stimulant and sedative substances and their implications for health and behavior.

Energy drinks flunitrazepam (Rophinol) cognition motor functions endurance

References (17)

  1. 1 Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug? [DOI]
  2. 2 Benzodiazepines revisited—will we ever learn? [DOI]
  3. 3 Benzodiazepine pharmacology and central nervous system-mediated effects.
  4. 4 Motor Coordination and Balance in Rodents [DOI]
  5. 5 The effects of Red Bull Energy Drink on human performance and mood [DOI]
  6. 6 Relative abuse liability of hypnotic drugs: a conceptual framework and algorithm for differentiating among compounds.
  7. 7 Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease [DOI]
  8. 8 Energy Drink Consumption : Beneficial and Adverse Health Effects [DOI]
  9. 9 Prescription Sedative Misuse and Abuse.
  10. 10 Interaction of Energy Drinks with Prescription Medication and Drugs of Abuse [DOI]
  11. 11 Combined Motor and Cognitive Rehabilitation: The Impact on Motor Performance in Patients with Mild Cognitive Impairment. Systematic Review and Meta-Analysis [DOI]
  12. 12 ENERGY DRINK CONSUMPTION: A SURVEY IN HIGH SCHOOL STUDENTS AND ASSOCIATED PSYCHOLOGICAL EFFECTS [DOI]
  13. 13 Histopathological Changes in the Myocardium Caused by Energy Drinks and Alcohol in the Mid-term and Their Effects on Skeletal Muscle Following Ischemia-reperfusion in a Rat Model [DOI]
  14. 14 Effects of caffeine administration on sedation and respiratory parameters in patients recovering from anesthesia [DOI]
  15. 15 Prevention of Drug-Induced Memory Impairment by Immunopharmacotherapy [DOI]
  16. 16 Effects of flunitrazepam on cognitive functions [DOI]
  17. 17 Pharmaceutics [DOI]

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