In vitro Antioxidant, Cytotoxic and Antibacterial Screening of the leaves of Acridocarpous orientalis, Native to Sultanate of Oman
Ahlam Al-Abri, Hazaa Al-Maqbali, Afaf Weli, Sadri Said, Amzad Hossain, Md. Sohail Akhtar
Journal of Pharmaceutical Research International · pp. 734–742 · Published 27 Jun 2013
10.9734/BJPR/2013/4113Abstract
Aims: To determine antioxidant, cytotoxic and antimicrobial activities of organic extracts from leaves of Acridocarpous orientalis (qafas) from Sultanate of Oman. Study Design: Brine shrimp test, DPPH assay and Disc diffusion method. Place and Duration of Study: School of Pharmacy, University of Nizwa, Oman, December 2012. Methodology: Hexane, chloroform, ethylacetate and hydroalcoholic extract were obtained by Kupchan’s partitioning of ethanol extract isolated from leaves of A. orientalis by maceration. Antioxidant activity was determined by free radical scavenging of (2,2-diphenyl-1-picrylhydrazyl, DPPH). The antimicrobial activity was checked using agar disc diffusion method against Gram-positive bacteria (Staphylococcus aureus) and two Gram-negative bacteria (Escherichia coli and Pseudomonus aeruginosa). Brine shrimp test was used to measure cytotoxic activity. Results: All extracts demonstrated potential antioxidant activities, hydroalcoholic extract showed the strongest activity (RC50 = 6.11 μg/ml). The order of antioxidant activity was hydro alcohol > ethyl acetate > chloroform > hexane extract. Ethylacetate extract showed low activity against Pseudomonus aeruginosa. None of the extracts was found to be active against brine shrimp larvae. Conclusion: A. orientalis could be considered as a good source of antioxidant compounds.
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