Skip to content
Research Article Open access CC BY 4.0

Induced and Constitutive Clindamycin Resistance in Staphylococcus spp. Strains Isolated from a Neonatal Intensive Care Unit

Sávio Benvindo Ferreira, José Ricardo Tomé Lopes Martins, Paula Benvindo Ferreira, Zilka Nanes Lima

International Journal of TROPICAL DISEASE & Health · pp. 1–8 · Published 19 Jun 2015

10.9734/IJTDH/2015/18522

Abstract

Aims: The hospital environment can act as a reservoir for microorganisms, which in turn can contaminate a range of hospital equipment and survive for long periods of time. One of these environments the Neonatal Intensive Care Unit (NICU), for the initial post partum period serving as a home for newborns of low birth weight and needing invasive procedures for administration of nutritional and medicinal substances, which makes the NICU a critical area for housing individuals with immune system. Thus, the aim of this study was to evaluate the phenotypic appearance of resistance of the Staphylococcus spp. compared to erythromycin and clindamycin, originating from isolated areas of a NICU in the city of Campina Grande - PB. Place and Duration of Study: Sample: Neonatal Intensive Care Unit of a public hospital in the city of Campina Grande – PB, Brazil. Processing and Analysis of Samples: Clinical Analysis Laboratory of the State University of Paraíba, between August and October 2012. Methodology: Samples were collected from surfaces present at the NICU. The samples were identified and strains of Staphylococcus spp. were subjected to sensitivity, and to verify erythromycin-induced resistance the D-test was used, following the CLSI standards-M100-S22 (2012). Results: Bacterial strains from all surfaces analyzed were isolated, 59.02% of isolates belong to the genus Staphylococcus spp., representing 36 bacterial strains, of which 31 were subspecies Staphylococcus aureus and 5 were coagulase-negative staphylococcus (CoNS). There was found more than 70% resistance to the group of penicillins and more than 30% to methicillin. Among the 36 strains of Staphylococcus spp. 19.45% were resistant to erythromycin. The rate found for constitutive resistance to macrolides (MLSBc) was 5.56% and was observed induced resistance to the macrolide type (MLSBi) in 2.78% the strains. Conclusion: The resistotyping of isolated strains for inducible and constitutive resistance may be considered a test of substantial importance not only as an epidemiologic marker in view of analyzing possible dissemination of hospital strains, but with respect to adequate, and precise determination of the antibiotic treatment of neonates.

Staphylococcus spp contaminated surfaces bacterial resistance MLSB.

References (11)

  1. 1 Mechanisms of Resistance to Macrolides and Lincosamides: Nature of the Resistance Elements and Their Clinical Implications [DOI]
  2. 2 Erythromycin resistance by ribosome modification [DOI]
  3. 3 Failure of Clindamycin Treatment of Methicillin-Resistant Staphylococcus aureus Expressing Inducible Clindamycin Resistance In Vitro [DOI]
  4. 4 Prevalence of macrolide-resistance genes in Staphylococcus aureus and Enterococcus faecium isolates from 24 European university hospitals [DOI]
  5. 5 Clindamycin treatment of methicillin-resistant Staphylococcus aureus infections in children [DOI]
  6. 6 Clindamycin treatment of Staphylococcus aureus expressing inducible clindamycin resistance [DOI]
  7. 7 Environmental contamination due to methicillin-resistant Staphylococcus aureus (MRSA) [DOI]
  8. 8 Microbial Flora on the Hands of Health Care Personnel: Differences in Composition and Antibacterial Resistance [DOI]
  9. 9 Methicillin-resistant Staphylococcus aureus on surfaces of an Intensive Care Unit [DOI]
  10. 10 Prevalence and mechanisms of erythromycin and clindamycin resistance in clinical isolates of β-haemolytic streptococci of Lancefield groups A, B, C and G in Seville, Spain [DOI]
  11. 11 Clinical significance of coagulase-negative staphylococci isolated from neonates [DOI]

Cited by 2

Clindamycin Resistance among Methicillin Resistant <i>Staphylococcus aureus</i> Isolated from Human and Respective Household Swine in Greater Kabale Region—South Western Uganda

Andrew Baguma, Benson Musinguzi, Moses Mpeirwe · Advances in Infectious Diseases · 2019

Showing 1 of 2 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

34

Page views

0

PDF downloads

4

Outbound clicks

2

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.