Skip to content
Research Article Open access CC BY 3.0

Intrinsic and Functional Properties of a Gelling Gum from Dioclea reflexa: A Potential Pharmaceutical Excipient

Philip F. Builders, Chukwuemeka C. Mbah, Anthony A. Attama

Journal of Pharmaceutical Research International · pp. 50–68 · Published 19 Mar 2012

10.9734/BJPR/2012/971

Abstract

Aims: Dioclea reflexa Hook F., is a woody vine widely distributed within tropical Africa and South America, in Nigeria flour prepared from the seeds is used as a soup thickener. The objectives of this study were to extract and modify the native gum from the seeds of D. reflexa, and evaluate their physicochemical and functional properties as a potential pharmaceutical excipient. Place and Duration of Study: Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. Between January 2009 and October 2010. And Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria. Between June 2010 and October 2011. Methodology: Native D. reflexa gum (DR-gum) was extracted from the seeds of D. reflexa and modified by ionotropic gelation in calcium chloride solution. The gum’s gel clarity and swelling in buffer solutions of different pH (4, 7, and 9.2), as well as the moisture sorption characteristics at different relative humidity (RH) were determined in relation to guar gum (G-gum). Also, the Fourier transform infrared (FT-IR) and Differential scanning calorimetry (DSC) analysis as well as the powders’ flow properties were evaluated. Results: DR-gum, XDR-gum and G-gum are typical hydrogels showing considerable responsiveness in swelling and gel clarity to changes in pH. The DSC thermographs of DR-gum and G-gum were similarly characterized by a glass transition and a cold crystallization transitions peaks as compared to the glass transition and melting transition peak of XDR-gum. The moisture sorption profile indicated that DR-gum and G-gum are moderately hygroscopic while XDR-gum is slightly hydroscopic. The FT-IR of the gums showed the basic differences in the functional groups of the respective polymer chain network. The bulk particles of the three gums showed comparative good flow. Conclusion: The basic similarities and differences in the physicochemical and functional properties of DR-gum and XDR-gum, and G-gum indicate their potential as a pharmaceutical excipient.

Guar gum Dioclea reflexa gum crosslinked Dioclea reflexa gum physicochemical properties functional properties.

References (36)

  1. 1 A simple equation for description of solute release II. Fickian and anomalous release from swellable devices [DOI]
  2. 2 Handbook of Pharmaceutical Excipients
  3. 3 The Useful Plants of West Tropical Africa [DOI]
  4. 4 Natural–origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications [DOI]
  5. 5 Starch paste clarity
  6. 6 Polymeric Plant-derived Excipients in Drug Delivery [DOI]
  7. 7 Pharmaceutical preformulation : the physicochemical properties of drug substances
  8. 8 Equilibrium Moisture Content of Pharmaceutical Excipients [DOI]
  9. 9 Moisture sorption–desorption–resorption characteristics and its effect on the mechanical behavior of the epoxy system [DOI]
  10. 10 Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon.
  11. 11 In vitro evaluation of guar gum as a carrier for colon-specific drug delivery [DOI]
  12. 12 Superabsorbency, pH-Sensitivity and Swelling Kinetics of Partially Hydrolyzed Chitosan-g-poly(Acrylamide) Hydrogels
  13. 13 Electrochemically Controlled Swelling and Mechanical Properties of a Polymer Nanocomposite [DOI]
  14. 14 Herbal excipients in novel drug delivery systems [DOI]
  15. 15 Molecular architectures and functional properties of gellan gum and related polysaccharides [DOI]
  16. 16 Preparation of poly(methacrylic acid-g-poly(ethylene glycol)) nanospheres from methacrylic monomers for pharmaceutical applications [DOI]
  17. 17 Effect of Glass Transition and Cross‐Linking on Rheological Properties of Gluten: Development of a Preliminary State Diagram [DOI]
  18. 18 Physical, Thermal and Sorption Profile of Starch Obtained fromTacca leontopetaloides [DOI]
  19. 19 Chemistry and properties of starch based desiccants [DOI]
  20. 20 Characterisation of particle properties and compaction behaviour of hydroxypropyl methylcellulose with different degrees of methoxy/hydroxypropyl substitution [DOI]
  21. 21 Refractive Index Matching: A General Method for Enhancing the Optical Clarity of a Hydrogel Matrix [DOI]
  22. 22 Novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose–starch microparticulate composites prepared by compatibilized reactive polymer blending [DOI]
  23. 23 Porosity–Pressure Functions [DOI]
  24. 24 Inulin hydrogels. I. Dynamic and equilibrium swelling properties [DOI]
  25. 25 Evaluation of Flow Properties of Dry Powder Inhalation of Salbutamol Sulfate with Lactose Carrier. [DOI]
  26. 26 Water sorption–desorption behaviour of methyl methacrylate–starch copolymers: effect of hydrophobic graft and drying method [DOI]
  27. 27 Preparation and characterization of mucinated agarose: A mucin–agarose physical crosslink [DOI]
  28. 28 The Carrageenan Connection IV [DOI]
  29. 29 A novel xyloglucan from seeds of Afzelia africana Se. Pers.—extraction, characterization, and conformational properties [DOI]
  30. 30 Thermal analysis of polymers [DOI]
  31. 31 Preparation and characterization of mucinated cellulose microparticles for therapeutic and drug delivery purposes [DOI]
  32. 32 Synthesis and swelling characteristics of semi-interpenetrating polymer network hydrogels composed of poly(acrylamide) and poly(γ-glutamic acid) [DOI]
  33. 33 Effect of polymer ratio and calcium concentration on gelation properties of gellan/gelatin mixed gels [DOI]
  34. 34 A novel xyloglucan gum from seeds ofAfzelia africanaSe. Pers.: Some functional and physicochemical properties [DOI]
  35. 35 Handbook of instrumental techniques for analytical chemistry [DOI]
  36. 36 Polymer characterization: physical techniques [DOI]

Cited by 21

Extracellular Enzymatic Activities of Endophytic Bacteria Isolates Obtained from Dioclea reflexa Hook Seeds

F.A. Ogundolie · Nigerian Journal of Biotechnology · 2024

Introduction to natural gums

Hira Munir, Ramsha Nasir, Saman Gull · Natural Gums · 2023

Showing 12 of 21 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

29

Page views

0

PDF downloads

8

Outbound clicks

21

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.