Skip to content
Research Article Open access CC BY 3.0

Limitations of Conventional Parameters and Role of Urinary Protein Biomarkers in the Determination of Drug Induced Acute Kidney Injury in Very Early Stage

R. Shanmuga Sundaram, B. R. Abhirama, L. Gowtham, Gladys Kalpana, M. Sudha, T. Thiyagarajan, S. Pushpa, G. K. Priyadharsini

Journal of Pharmaceutical Research International · pp. 2463–2474 · Published 24 Oct 2014

10.9734/BJPR/2014/13446

Abstract

Drug-induced Acute Kidney Injury (AKI) constitutes an important cause of acute renal failure and chronic kidney disease in present day clinical practice. Drug-induced acute renal failure (ARF) accounted for 20% of all ARF in an Indian study. The incidence and prevalence of chronic kidney disease (CKD) has dramatically increasing worldwide. Progression of AKI from mild or moderate to end stage may be prevented by selecting potentially effective therapies, if it is detected in very early stage. But early detection of AKI is often difficult due to paucity of early predictive noninvasive biomarkers. Development of omics technology has led to the identification of several urinary protein biomarkers and transcriptional biomarkers, which enable earlier detection of kidney injury. Urinary protein biomarkers have great benefit due to the easy or non-invasive availability of urine and many showing good predictive power. Several urinary protein biomarkers have been identified and have demonstrated superiority in detecting kidney injury in comparison to conventional parameters like serum creatinine (SCr), blood urea nitrogen (BUN) etc. These promising experimental biomarker of kidney damage require further confirmation of its use in routine clinical use.

Kidney injury biomarkers acute renal failure SCr BUN omics

References (65)

  1. 1 Identification of Neutrophil Gelatinase-Associated Lipocalin as a Novel Early Urinary Biomarker for Ischemic Renal Injury [DOI]
  2. 2 Kidney Injury Molecule-1 (KIM-1), a Putative Epithelial Cell Adhesion Molecule Containing a Novel Immunoglobulin Domain, Is Up-regulated in Renal Cells after Injury [DOI]
  3. 3 Molecular events associated with reactive oxygen species and cell cycle progression in mammalian cells [DOI]
  4. 4 Sensitivity and Specificity of a Single Emergency Department Measurement of Urinary Neutrophil Gelatinase–Associated Lipocalin for Diagnosing Acute Kidney Injury [DOI]
  5. 5 Urinary IL-18 is an early predictive biomarker of acute kidney injury after cardiac surgery [DOI]
  6. 6 Urine IL-18 Is an Early Diagnostic Marker for Acute Kidney Injury and Predicts Mortality in the Intensive Care Unit [DOI]
  7. 7 Urinary interleukin-18 is a marker of human acute tubular necrosis [DOI]
  8. 8 Urine NGAL and IL-18 are Predictive Biomarkers for Delayed Graft Function Following Kidney Transplantation [DOI]
  9. 9 Clusterin: Physiologic and pathophysiologic considerations [DOI]
  10. 10 Urinary Biomarkers in the Early Detection of Acute Kidney Injury after Cardiac Surgery [DOI]
  11. 11 Two faces of p53: aging and tumor suppression [DOI]
  12. 12 Urinary cystatin C as an early biomarker of acute kidney injury following adult cardiothoracic surgery [DOI]
  13. 13 Renal L-Type Fatty Acid–Binding Protein in Acute Ischemic Injury [DOI]
  14. 14 Biomarkers of nephrotoxic acute kidney injury [DOI]
  15. 15 Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer [DOI]
  16. 16 Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium [DOI]
  17. 17 Prognostic Value of Tubular Proteinuria and Enzymuria in Nonoliguric Acute Tubular Necrosis [DOI]
  18. 18 Creatinine determination according to Jaffe--what does it stand for? [DOI]
  19. 19 Acute kidney injury: epidemiology and diagnostic criteria [DOI]
  20. 20 Lipocalin 2 Is Required for Pulmonary Host Defense against Klebsiella Infection [DOI]
  21. 21 Measurement of cystatin-C and creatinine in urine [DOI]
  22. 22 Blood Urea Nitrogen and Serum Creatinine [DOI]
  23. 23 Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease [DOI]
  24. 24 Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury [DOI]
  25. 25 Urinary fatty acid-binding protein 1: an early predictive biomarker of kidney injury [DOI]
  26. 26 Evaluation of 32 urine biomarkers to predict the progression of acute kidney injury after cardiac surgery [DOI]
  27. 27 Urinary Interleukin 18 for Detection of Acute Kidney Injury: A Meta-analysis [DOI]
  28. 28 Evaluation of Putative Biomarkers of Nephrotoxicity after Exposure to Ochratoxin A In Vivo and In Vitro [DOI]
  29. 29 Neutrophil gelatinase-associated lipocalin (NGAL) in inflammatory bowel disease: association with pathophysiology of inflammation, established markers, and disease activity [DOI]
  30. 30 Monitoring of Urinary L-Type Fatty Acid-Binding Protein Predicts Histological Severity of Acute Kidney Injury [DOI]
  31. 31 Biological Qualification of Biomarkers of Chemical-Induced Renal Toxicity in Two Strains of Male Rat [DOI]
  32. 32 Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies [DOI]
  33. 33 A Tool for Biomarker Discovery in the Urinary Proteome: A Manually Curated Human and Animal Urine Protein Biomarker Database [DOI]
  34. 34 Glutathione S-Transferases: Biomedical Applications [DOI]
  35. 35 Early risk assessment of severe preeclampsia: Admission battery of symptoms and laboratory tests to predict likelihood of subsequent significant maternal morbidity [DOI]
  36. 36 Urinary L-type fatty acid-binding protein as a new biomarker of sepsis complicated with acute kidney injury* [DOI]
  37. 37 Prevalence and socio-economic aspects of chronic kidney disease [DOI]
  38. 38 Elevation of serum and urine levels of TIMP-1 and tenascin in patients with renal disease [DOI]
  39. 39 Diagnosis and Management of Atypical Preeclampsia-Eclampsia [DOI]
  40. 40 Vanin-1; a potential biomarker for nephrotoxicant-induced renal injury [DOI]
  41. 41 Pathogenetic mechanisms in nephrotoxic acute renal failure.
  42. 42 Proteomic identification of vanin-1 as a marker of kidney damage in a rat model of type 1 diabetic nephropathy [DOI]
  43. 43 Prevalence of chronic kidney disease and its associated risk factors: the first report from Iran using both microalbuminuria and urine sediment.
  44. 44 Evaluation of serum and urine clusterin as a potential tumor marker for urinary bladder cancer.
  45. 45 Urinary levels of matrix metalloproteinases and their tissue inhibitors in nephrotic children [DOI]
  46. 46 Proteomic investigation of urinary markers of carbon-tetrachloride-induced hepatic fibrosis in the Hanover Wistar rat [DOI]
  47. 47 BUN/Cr Ratio as an Index of Gastrointestinal Bleeding Mass in Children [DOI]
  48. 48 Blood urea nitrogen/creatinine ratio in rhabdomyolysis [DOI]
  49. 49 Hypovolemia and dehydration in the oncology patient.
  50. 50 Concerns about KIM-1 as a urinary biomarker for acute tubular necrosis (ATN) [DOI]
  51. 51 Urine NGAL Predicts Severity of Acute Kidney Injury After Cardiac Surgery [DOI]
  52. 52 Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury [DOI]
  53. 53 Impaired IL-18 processing protects caspase-1–deficient mice from ischemic acute renal failure [DOI]
  54. 54 Drug-induced nephrotoxicity [DOI]
  55. 55 Matrix Metalloproteinases in Renal Development and Disease [DOI]
  56. 56 Comparative Analysis of Novel Noninvasive Renal Biomarkers and Metabonomic Changes in a Rat Model of Gentamicin Nephrotoxicity [DOI]
  57. 57 Non-traumatic rhabdomyolysis and acute renal failure.
  58. 58 Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury [DOI]
  59. 59 Novel Assays for Detection of Urinary KIM-1 in Mouse Models of Kidney Injury [DOI]
  60. 60 Urinary Albumin Excretion in Early and Long-Term Juvenile Diabetes [DOI]
  61. 61 Urinary glutathione S-transferase as an early marker for renal dysfunction in patients admitted to intensive care with sepsis [DOI]
  62. 62 Elevated levels of serum creatinine: recommendations for management and referral.
  63. 63 Urinary Clusterin in Chronic Nephrotoxicity in the Rat [DOI]
  64. 64 Drug induced renal disease.
  65. 65 Radioimmunoassay Measurement of Urinary Ligandin Excretion in Nephrotoxin-Treated Rats [DOI]

Cited by 7

Investigation of new biomarkers of kidney injury in renal transplant recipients undergoing graft biopsy

A. Michon, A. Durrbach, Jean-Charles Gautier · Clinical Transplantation · 2021

Effects of Genetic Polymorphism on Susceptibility to Nephrotoxic Properties of BTEXs Compounds

M. Neghab, M. Nourozi, S. Shahtaheri · Journal of Occupational and Environmental Medicine · 2018

Showing 3 of 7 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

51

Page views

0

PDF downloads

10

Outbound clicks

7

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.