Skip to content
Research Article Open access CC BY 4.0

Microbial Diseases of Laboratory Animals and its monitoring Tools

Rekha Manivannan, Tamilselvan Chidambaram, Ramani Gopal, King Solomon Ebenezer

Journal of Advances in Microbiology · pp. 31–46 · Published 21 Feb 2024

10.9734/jamb/2024/v24i2794

Abstract

Microbial diseases pose significant challenges in experimental research, impacting both animal welfare and research outcomes. The review covers a wide range of microbial pathogens, including bacteria, viruses, fungi, and parasites, that commonly affect laboratory animals. It explores the etiology, pathogenesis, and clinical manifestations associated with these pathogens, highlighting their influence on experimental results. Extensively discussed about the monitoring assays employed for microbial disease detection in experimental animals. Traditional and modern techniques are considered, including microbiological culturing, serological assays, molecular diagnostics, histopathology, and advanced imaging methods. Regular health monitoring programs for laboratory animals, emphasizing the significance of early detection and intervention to prevent disease outbreaks and maintain animal welfare. Emerging trends and technologies in microbial disease monitoring, such as next-generation sequencing, metagenomics, and high-throughput screening, are also explored. This review aims to provide researchers, laboratory animal professionals, and regulatory authorities with a comprehensive resource for understanding microbial diseases in experimental animals and selecting appropriate monitoring assay. For the Scientists and Veterinarians this overall review gives a glimpse for implementing effective monitoring strategies, identifying and managing microbial diseases, ensuring the well-being of laboratory animals. The synthesis of current knowledge and best practices will enhance the scientific rigor and reproducibility of experimental studies involving animals. In conclusion, this review emphasizes the critical importance of microbial disease monitoring in experimental animals. Robust and accurate monitoring assays enable researchers to effectively detect and manage microbial diseases, safeguarding animal health and ensuring reliable research outcomes.

Bacteria fungi viruses next generation sequencing ELISA PCR

References (54)

  1. 1 Inflammatory responses and inflammation-associated diseases in organs [DOI]
  2. 2 Interaction between microbiota and immunity in health and disease [DOI]
  3. 3 Western blot: Technique, theory, and trouble shooting [DOI]
  4. 4 Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution [DOI]
  5. 5 PCR-based diagnostics for infectious diseases: uses, limitations, and future applications in acute-care settings [DOI]
  6. 6 Administration of substances to laboratory animals: routes of administration and factors to consider.
  7. 7 Veterinary Microbiology and Microbial Disease
  8. 8 The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species [DOI]
  9. 9 Anti-Immunology: Evasion of the Host Immune System by Bacterial and Viral Pathogens [DOI]
  10. 10 Translating RNA sequencing into clinical diagnostics: opportunities and challenges [DOI]
  11. 11 Zoonotic Diseases: Etiology, Impact, and Control [DOI]
  12. 12 Virus entry: molecular mechanisms and biomedical applications [DOI]
  13. 13 Immunity and immunopathology to viruses: what decides the outcome? [DOI]
  14. 14 Current challenges and best-practice protocols for microbiome analysis [DOI]
  15. 15 Role of Cell Culture for Virus Detection in the Age of Technology [DOI]
  16. 16 Animals as sources of food-borne pathogens: A review [DOI]
  17. 17 Helminth Infections and Host Immune Regulation [DOI]
  18. 18 Shiga Toxin (Stx) Classification, Structure, and Function [DOI]
  19. 19 Metagenomic Pyrosequencing and Microbial Identification [DOI]
  20. 20 Whole-Genome Sequencing of Bacterial Pathogens: the Future of Nosocomial Outbreak Analysis [DOI]
  21. 21 Bacterial culture through selective and non-selective conditions: the evolution of culture media in clinical microbiology [DOI]
  22. 22 Virus–Receptor Interactions: The Key to Cellular Invasion [DOI]
  23. 23 Veterinary Microbiology and Microbial Disease [DOI]
  24. 24 The Yersiniae — a model genus to study the rapid evolution of bacterial pathogens [DOI]
  25. 25 Adhesins in Human Fungal Pathogens: Glue with Plenty of Stick [DOI]
  26. 26 Whole-Genome Sequencing in Outbreak Analysis [DOI]
  27. 27 Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin [DOI]
  28. 28 Typing methods based on whole genome sequencing data [DOI]
  29. 29 Practical Guidance for Clinical Microbiology Laboratories: Laboratory Diagnosis of Parasites from the Gastrointestinal Tract [DOI]
  30. 30 Evaluation of SARS‐CoV‐2 neutralizing antibodies using a CPE‐based colorimetric live virus micro‐neutralization assay in human serum samples [DOI]
  31. 31 Prion Diseases: From Protein to Cell Pathology [DOI]
  32. 32 Adherence mechanisms in human pathogenic fungi [DOI]
  33. 33 Mycoplasma pneumonia: Clinical features and management [DOI]
  34. 34 Evaluation and Comparison of Serological Methods for COVID-19 Diagnosis [DOI]
  35. 35 Cell Cultures for Virology: Usability, Advantages, and Prospects [DOI]
  36. 36 Adhesins in the virulence of opportunistic fungal pathogens of human [DOI]
  37. 37 An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers [DOI]
  38. 38 Cellular Biology of Prion Diseases [DOI]
  39. 39 Neuroparasitic Infections: Cestodes, Trematodes, and Protozoans [DOI]
  40. 40 Mechanisms of Microbial Infections [DOI]
  41. 41 Prion Protein Misfolding, Strains, and Neurotoxicity: An Update from Studies on Mammalian Prions [DOI]
  42. 42 Cultivation of parasites [DOI]
  43. 43 Diagnostic Performance of Serological Tests to Detect Antibodies Against Acute Scrub Typhus Infection in Central India [DOI]
  44. 44 Role of Prion Protein Aggregation in Neurotoxicity [DOI]
  45. 45 Nutrient Acquisition and Attachment Strategies in Basal Lineages: A Tough Nut to Crack in the Evolutionary Puzzle of Apicomplexa [DOI]
  46. 46 Conformational conversion of prion protein in prion diseases [DOI]
  47. 47 Presence of Cross-Reactions with Other Viral Encephalitides in the Indirect Fluorescent-Antibody Test for Diagnosis of Rabies [DOI]
  48. 48 Novel Immunofluorescence Assay Using Recombinant Nucleocapsid-Spike Fusion Protein as Antigen To Detect Antibodies against Severe Acute Respiratory Syndrome Coronavirus [DOI]
  49. 49 Welfare of domestic fowl and other captive birds
  50. 50 Nested Polymerase Chain Reaction (PCR) [DOI]
  51. 51 Nutritional immunity: the battle for nutrient metals at the host–pathogen interface [DOI]
  52. 52 Western blot: Technique, theory and trouble shooting [DOI]
  53. 53 Next Generation and Other Sequencing Technologies in Diagnostic Microbiology and Infectious Diseases [DOI]
  54. 54 A Review of Zoonotic Disease Threats to Pet Owners: A Compendium of Measures to Prevent Zoonotic Diseases Associated with Non-Traditional Pets Such as Rodents and Other Small Mammals, Reptiles, Amphibians, Backyard Poultry, and Other Selected Animals [DOI]

Cited by 6

Laboratuvar Hayvanlarında Tarama Programlarının Önemi ve Bazı Önemli Viral Ajanların Araştırılması

Erdal Polat, Hayrunnisa Bostan Yörü, Yasin Kalay · Laboratuvar Hayvanları Bilimi ve Uygulamaları Dergisi · 2024

Showing 2 of 6 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

26

Page views

0

PDF downloads

4

Outbound clicks

6

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.