Molecular Docking Evaluation of the Desert Truffles as Potent Antifungal Inhibitors
Ghassab M. Al-Mazaideh, Farhan K. Al-Swailmi, Mujeeb Ur Rehman Parrey
Journal of Pharmaceutical Research International · pp. 36–48 · Published 27 Feb 2021
10.9734/jpri/2021/v33i531179Abstract
The research investigated the possible antifungal behavior of forty-four truffles bioactive compounds conducted to investigate the interaction modes of these inhibitors against three different types of the fungal proteins: Candida albicans, Blastomyces dermatitidis, and Ganoderma microsporum. The applied method in contrast to ketoconazole and griseofulvin revealed the possible anti-fungal agents ergosterol, Catechin gallate and rutin. With respect to Candida Albicans, the maximum possible binding energy was ergosterol (-11.75 Kcal/mol), followed then by catechin gallate (-11.46 Kcal/mol) then rutin (-9.90 Kcal/mol). Compared to Blastomyces, Ganoderma microsporum fungal protein with most negative binding energy among other components of the truffle is found to be of a relatively similar behavior for the same compounds. Ergosterol demonstrated the highest binding capacity for dermatitidis, while rutin scored the lowest against Ganoderma microsporum. The possible anti-fungal components of desert truffle have yet to be studied in vitro in the future.
Cited by 10
Camila Eduarda Justen, Alana Bianca de Moraes Chitolina, Isabela Andres Finamor · Journal of Toxicology and Environmental Health, Part A · 2025
Rafaela da Silva Rangel, Raquel Tusi Tamiosso, Rúbia Schallenberger da Silva · Microbial Pathogenesis · 2025
Mohammed Helmy Faris Shalayel, Ghassab M. Al-Mazaideh, Majed Meshal Almutairi · Natural Product Communications · 2024
Mahmoud Khalid, Fuad Al-Rimawi, Sama Darwish · Natural Product Communications · 2024
Mohamed E. M. Abdelbagi, Ghassab M. Al-Mazaideh, Adil Elhag Ahmed · Processes · 2023
Showing 5 of 10 known citations — external sources report more than can currently be individually listed.
Related research
- Knowledge, Attitude and Predisposing Risk Factors of Non-Albican Vulvovaginal Candidiasis among Symptomatic Women in Port Harcourt — shares topic coverage
- Aetiologic Agents of Vaginitis in Sexually Active Women in a Traditional Sprawling Town in the Niger Delta, South – South Nigeria — shares topic coverage
- The Prevalence of Candida albicans and Trichomonas vaginalis among First Year Female Students of a Tertiary Institution in Southeastern Nigeria — shares topic coverage
- Biodegradation of Palm Oil Mill Effluent (POME) and Lipase Activity by Pseudomonas aeruginosa, Bacillus subtilis and Candida albicans — shares topic coverage
- Characterization of Vaginal Lactobacillus Strains and Their Potential Antagonistic Effects on Candida albicans — shares topic coverage
Article metrics
Real usage data collected on this platform.
28
Page views
0
PDF downloads
8
Outbound clicks
10
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.