Multisystem Inflammatory Syndrome in Children- A Case Study from a Tertiary Care Centre in Maharashtra, India

Abstract

Background: A multisystem inflammatory syndrome in children (MIS-C) is associated with coronavirus disease 2019. Understanding the epidemiology and clinical course of multisystem inflammatory syndrome in children (MIS-C) and its association with Covid-19 is important, given the clinical and public health implications of the syndrome. Materials and Methods: This was a prospective observational study carried out in the Department of Paediatrics, Krishna Institute Of Medical Sciences, Karad, Maharashtra, India, over a period of 12 months. Thirty three children, between the ages of 1 month-14 years were studied. Results: Out of the 67 patients admitted to our paediatrics ward during this period with suspected MISC, 33 patients were confirmed to have MIS-C on laboratory investigations. Involvement of a minimum of two systems was noted. The main clinical manifestations were gastrointestinal (abdominal pain, nausea and vomiting and diarrhoea) and dermatological (rash). Fever was present in all 33 cases. The laboratory investigations were indicative of a pro inflammatory state seen in MIS-C. Positive findings on echocardiography were found in majority of cases. Conclusion: Multisystem inflammatory syndrome in children associated with SARS-CoV-2 has become serious public health problem in the paediatric population, with haemodynamic instability and cardiac dysfunction being the main signs, and rapid resolution with anti-inflammatory therapy.