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Research Article Open access CC BY 4.0

N-chlorotaurine and N-bromotaurine Combination Regimen for the Cure of Valacyclovir-unresponsive Herpes Zoster Comorbidity in a Multiple Sclerosis Patient

Anthony M. Kyriakopoulos, Stella Logotheti, Janusz Marcinkiewicz, Markus Nagl

International Journal of Medical and Pharmaceutical Case Reports · pp. 1–6 · Published 3 May 2016

10.9734/IJMPCR/2016/25476

Abstract

Aims: Skin herpes zoster frequently affects immunocompromised patients including multiple sclerosis patients that belong to a distinct category of autoimmunity. Although considered a manageable condition, non-immunocompetent patients are suboptimally targeted by the gold standard valacyclovir treatment. In the case presented here, a new endogenous antiseptic treatment was applied. Presentation of Case: We describe a recurrent multiple sclerosis patient with herpes zoster skin infection, who was unresponsive to cotreatment with valacyclovir. Topical application of 0.8% N-chlorotaurine twice daily for four days resulted in immediate symptom resolution including loss of pain. Alternating application of 0.8% N-chlorotaurine and 1.0% N-bromotaurine in the next three days led to rapid healing. Discussion and Conclusion: This is the first case where natural taurine haloamines (N-chlorotaurine and N-bromotaurine), which are involved in innate immunity, were applied in reactivated, painful herpes zoster. The rapid clinical healing observed suggests specific investigations of the therapeutic effect of these compounds in this indication.

N-bromotaurine N-chlorotaurine herpes zoster immuno-modulation valacyclovir glatiramer acetate.

References (22)

  1. 1 Multiple Sclerosis — The Plaque and Its Pathogenesis [DOI]
  2. 2 Recommendations for the Management of Herpes Zoster [DOI]
  3. 3 Herpes Zoster [DOI]
  4. 4 Taurine and inflammatory diseases [DOI]
  5. 5 Acute Pain in Herpes Zoster and Its Impact on Health-Related Quality of Life [DOI]
  6. 6 Diagnosis and Assessment of Pain Associated With Herpes Zoster and Postherpetic Neuralgia [DOI]
  7. 7 Varicella-Zoster Virus Infections in Patients Treated With Fingolimod [DOI]
  8. 8 N-chlorotaurine, a natural antiseptic with outstanding tolerability [DOI]
  9. 9 The mechanism of action of glatiramer acetate in multiple sclerosis and beyond [DOI]
  10. 10 IgG Antibodies against Measles, Rubella, and Varicella Zoster Virus Predict Conversion to Multiple Sclerosis in Clinically Isolated Syndrome [DOI]
  11. 11 Update on Varicella Zoster Virus Vasculopathy [DOI]
  12. 12 Clinical and Virologic Characterization of Acyclovir‐Resistant Varicella‐Zoster Viruses Isolated from 11 Patients with Acquired Immunodeficiency Syndrome [DOI]
  13. 13 Multiple Sclerosis in Latin America [DOI]
  14. 14 Is there a role of taurine bromamine in inflammation? Interactive effects with nitrite and hydrogen peroxide [DOI]
  15. 15 Brief Presence of Varicella-zoster Viral DNA in Mononuclear Cells During Relapses of Multiple Sclerosis [DOI]
  16. 16 Topical taurine bromamine, a new candidate in the treatment of moderate inflammatory acne vulgaris: a pilot study. [DOI]
  17. 17 Activity of N-chlorotaurine against herpes simplex- and adenoviruses [DOI]
  18. 18 Frequent association of multiple sclerosis with varicella and zoster [DOI]
  19. 19 Varicella Zoster Virus and Relapsing Remitting Multiple Sclerosis [DOI]
  20. 20 The role of heme oxygenase-1 in down regulation of PGE2 production by taurine chloramine and taurine bromamine in J774.2 macrophages [DOI]
  21. 21 Herpes zoster with progression to acute varicella zoster virus‐meningoencephalitis [DOI]
  22. 22 An Unusual Presenting Complaint for Herpes Zoster [DOI]

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