One-pot Multi-component Synthesis of Some Pharmacologically Significant 2,4,5-Tri and  1,2,4,5-Tetrasubstituted Imidazoles: A Review

Ravi Bansal; Pradeep K. Soni; Mukesh K. Ahirwar; Anand K. Halve

doi:10.9734/IRJPAC/2016/24493

Research Article Open access CC BY 4.0

One-pot Multi-component Synthesis of Some Pharmacologically Significant 2,4,5-Tri and 1,2,4,5-Tetrasubstituted Imidazoles: A Review

Ravi Bansal, Pradeep K. Soni, Mukesh K. Ahirwar, Anand K. Halve

International Research Journal of Pure and Applied Chemistry · pp. 1–26 · Published 14 Jun 2016

10.9734/IRJPAC/2016/24493

Abstract

Heterocyclic compounds are acquiring more importance in recent years because of their pharmacological activities. Compounds containing imidazole moiety have many pharmacological properties and play important role in biochemical processes. Imidazole is a natural compound which exists in many important natural molecules such as the amino acid histidine, vitamin B12, histamine, biotin and purines like adenine and guanine. Imidazole derivatives play significant roles in various pharmacological activities such as anticancer, antibacterial, antifungal, antiviral, anti-HIV and antitubercular. This article aims to review the work in the methods of synthesis using various catalytic system, solvent condition and pharmacological potential of 2,4,5-tri and 1,2,4,5-tetrasubstituted imidazoles reported during last 15 years.

Multi-component reactions heterocycles substituted imidazoles pharmacological activities

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Ravi Bansal, Pradeep K. Soni, Mukesh K. Ahirwar, Anand K. Halve (2016). One-pot Multi-component Synthesis of Some Pharmacologically Significant 2,4,5-Tri and 1,2,4,5-Tetrasubstituted Imidazoles: A Review. International Research Journal of Pure and Applied Chemistry , 1–26. https://doi.org/10.9734/IRJPAC/2016/24493

Affiliations

Ravi Bansal — School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.)-474011, India
Pradeep K. Soni — School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.)-474011, India
Mukesh K. Ahirwar — Govt. Maharaja Autonomous P.G. College, Chhatarpur (M.P.), India
Anand K. Halve — School of Studies in Chemistry, Jiwaji University, Gwalior (M.P.)-474011, India

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