Oral Administration of Euterpe oleracea Mart., Its Influence over Body Weight and Lymphoid Organs and Alterations in Haematological and Glycaemical Parameters
Mayara T. Pinheiro, Nayara S. R. Silva, Cleison C. Lobato, Francinaldo S. Braga, César F. Santos, Josivan S. Costa, José Carlos T. Carvalho, Cleydson Breno R. Santos
Journal of Pharmaceutical Research International · pp. 2484–2493 · Published 24 Oct 2014
10.9734/BJPR/2014/10354Abstract
Aims: The aims of the study were to evaluate alterations caused by the oral administration of the aqueous extract of Euterpe oleracea to non-isogenic adult male mice during 15 and 30 consecutive days through the comparison of body and spleen weights, number of splenic and medullary cells, their hemogram and glycemia indices. Study Design: Animals were divided into 8 groups (5 animals/group). Treated groups received the AEA concentration (125 mg/ml by gavage) at doses of 5, 50 and 500mg/kg for 15 and 30 days. The control group received only the vehicle of dilution (1x PBS) in volume of 0.5 ml. After treatment the animals were sacrificed in a CO2 chamber for testing. Place and Duration of Study/Methodology: The aqueous extract of concentration of 125 mg/ml of lyophilized açaí pulp was prepared in Laboratory of General and Analytical Chemistry of Federal University of Amapá. Values of body weight, weight of liver and spleen, number of spleen and bone marrow cells, blood count and glucose of the mice were conducted on Drugs Research Laboratory between January and November of 2013. Results: The statistical analysis was done by ANOVA test two-way with significance level p<0.05 in relation to control followed by Tukey post-test. The AEA caused significant changes in body weight, about 22% in animals treated with 500 mg/kg. Weight of spleen showed no significant changes, there was statistical difference in blood glucose levels between groups 5 and 500 mg/kg treated for 15 days and punctually in the 500 mg/kg group treated for 15 and 30 days. It was observed that the treatment with the AEA doses (5, 50 and 500 mg/kg) for 30 days increased the number of bone marrow cells. Regarding the number of spleen cells, treatment promoted changes, reducing the amount of cells during the 30 days of treatment, principally at the dose of 50 mg/kg. During the 15 day treatment of 500 mg/kg there was an increase in the number of spleen cells. Conclusion: The treatment of mice with aqueous extract of açaí pointed that the concentration has significant influence in: 1) glucose concentration in the blood; 2) The increased number of bone marrow cells; 3) and the number of spleen cells. Thus, comparison between groups of animals was compatible with the hypothesis that the increase in body mass is a risk factor for insulin resistance.
References (28)
- 1 Dietary Fat Intake and the Risk of Coronary Heart Disease in Women [DOI]
- 2 Antioxidant Activity of Anthocyanins and Their Aglycons [DOI]
- 3 Human Physiology: An Integrated Approach
- 4 How to correctly determine the different chlorophyll fluorescence parameters and the chlorophyll fluorescence decrease ratio RFd of leaves with the PAM fluorometer [DOI]
- 5 Mechanisms by which Dietary Fatty Acids Modulate Plasma Lipids [DOI]
- 6 Inducible nitric oxide synthase (iNOS) in tumor biology: The two sides of the same coin [DOI]
- 7 Twenty-five years of research on medicinal plants in Latin America [DOI]
- 8 Phytochemical and Nutrient Composition of the Freeze-Dried Amazonian Palm Berry, Euterpe oleraceae Mart. (Acai) [DOI]
- 9 Medicinal and poisonous diversity of the flora of “Cariri Paraibano”, Brazil [DOI]
- 10 Oral administration of Eclipta alba leaf aqueous extract enhances the non-specific immune responses and disease resistance of Oreochromis mossambicus [DOI]
- 11 Chemical Composition, Antioxidant Properties, and Thermal Stability of a Phytochemical Enriched Oil from Açai (Euterpe oleraceaMart.) [DOI]
- 12 Antiproliferative and antioxidant properties of anthocyanin-rich extract from açai [DOI]
- 13 Açai (Euterpe oleracea Mart.) Polyphenolics in Their Glycoside and Aglycone Forms Induce Apoptosis of HL-60 Leukemia Cells [DOI]
- 14 Effects of Açai (Euterpe oleracea Mart.) berry preparation on metabolic parameters in a healthy overweight population: A pilot study [DOI]
- 15 Endothelium-dependent vasodilator effect of Euterpe oleracea Mart. (Açaí) extracts in mesenteric vascular bed of the rat [DOI]
- 16 Euterpe oleracea juice as a functional pigment for yogurt [DOI]
- 17 Antimalarial remedies in French Guiana: A knowledge attitudes and practices study [DOI]
- 18 Immunostimulatory effect of Tinospora cordifolia Miers leaf extract in Oreochromis mossambicus.
- 19 Medicinal uses of South American palms [DOI]
- 20 Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression [DOI]
- 21 Immunostimulatory effect of Silybum Marianum (milk thistle) extract.
- 22 Effect of guar gum on body-weight, hunger ratings and metabolism in obese subjects [DOI]
- 23 Identificação e quantificação das antocianinas do fruto do açaizeiro (Euterpe oleracea) Mart [DOI]
- 24 The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice [DOI]
- 25 Immunostimulatory effects of extract of Pulicaria crispa before and after Schistosoma mansoni infection.
- 26 Effects of Agaricus blazei Murill extract on immune responses in normal BALB/c mice.
- 27 Leukopenia and altered hematopoietic activity in mice exposed to the abused inhalant, isobutyl nitrite.
- 28 Deleterious effects ofEchinacea purpureaand melatonin on myeloid cells in mouse spleen and bone marrow [DOI]
Cited by 0
No indexed citations yet.
Related research
- Effect of Crude Ethanol Leaf-extract of Murraya koenigii on Anxiety in Mice — shares topic coverage
- Liver Profile of Artemether-lumefantrine-tinidazole in Healthy and Parasitized Mice — shares topic coverage
- Harnessing Ashitaba Extract: A Promising Solution for Regulating Blood Glucose in High Glucose Diet Mice — shares topic coverage
- Evaluation of Anti-malarial Profile of Methanol Leaf Extract of Jatropha curcas Linn on Plasmodium berghei Infection in Mice — shares topic coverage
- Histological Effect of Static Magnetic Fields on Testis and Epididymis in Male Mice — shares topic coverage
Article metrics
Real usage data collected on this platform.
13
Page views
0
PDF downloads
1
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.