Phytochemical Analysis and Anti-diabetic Potential of Annona muricata L., Persea americana Mill. and Montrichardia arborescens L. Schott Utilized by the Residents of Pakuri (St. Cuthbert’s Mission)  in Guyana

Cecil Boston; Judith Rosales; Jaipaul Singh

doi:10.9734/jocamr/2019/v8i430130

Research Article Open access CC BY 4.0

Phytochemical Analysis and Anti-diabetic Potential of Annona muricata L., Persea americana Mill. and Montrichardia arborescens L. Schott Utilized by the Residents of Pakuri (St. Cuthbert’s Mission) in Guyana

Cecil Boston, Judith Rosales, Jaipaul Singh

Journal of Complementary and Alternative Medical Research · pp. 1–12 · Published 12 Feb 2020

10.9734/jocamr/2019/v8i430130

Abstract

Aim: This study was designed to assess the utilization of plants with anti-diabetic properties and to conduct preliminary phytochemical analysis and moreover, to assess the anti-diabetic potential of selected plants used to treat and manage Type 2 diabetes mellitus (T2DM) among the residents of Pakuri (St. Cuthbert’s Mission) in Guyana. Methodology: The leaves of sour sop (Annona muricata L.), pear (Persea americana Mill.) and Mocou-Mocou (Montrichardia arborescens L. Schott) underwent phytochemical testing and a-amylase Inhibition testing to determine their anti-diabetic properties. Results: This study showed that the leaves of pear, sour sop and mocou mocou contained different chemical constituents including alkaloids, flavonoids, saponins and tannins but the absence of amino acids (proteins), carbohydrates and glycosides. The a-amylase inhibitory studies performed demonstrated that the extracts of A. muricata in ethanol and chloroform had significant inhibitory potential. Conclusion: Considering the promising potential of phytochemicals and the anti-diabetic activity of these species of plant extracts in anti-diabetic drug development, in vivo experiments and clinical trials are required for efficacy and safety evaluation. Also, the anti-diabetic phytochemicals may be used in combination with existing orthodox drugs, thereby, reducing the dose of synthetic anti-diabetic drugs, which will help in addressing the toxicity and cost-related issues in chronic use during the management of diabetes mellitus (DM).

Traditional medicine type 2 diabetes mellitus complementary and alternative medicine indigenous knowledge attitude.

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Cecil Boston, Judith Rosales, Jaipaul Singh (2020). Phytochemical Analysis and Anti-diabetic Potential of Annona muricata L., Persea americana Mill. and Montrichardia arborescens L. Schott Utilized by the Residents of Pakuri (St. Cuthbert’s Mission) in Guyana. Journal of Complementary and Alternative Medical Research , 1–12. https://doi.org/10.9734/jocamr/2019/v8i430130

Affiliations

Cecil Boston — Faculty of Health Sciences, University of Guyana, Turkeyen Campus, Guyana.
Judith Rosales — Faculty of Earth and Environmental Sciences, University of Guyana, Turkeyen Campus, Guyana.
Jaipaul Singh — School of Forensic and Applied Sciences, University of Central Lancashire, Preston, Lancashire, PR1 2HE, England, United Kingdom.

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