Skip to content
Research Article Open access CC BY 3.0

Phytochemical Constitutents and Antidiabetic Property of Cola nitida Seeds on Alloxan-Induced Diabetes Mellitus in Rats

Iliemene Uju Dorathy, Shekins O. Okere, Eze Ejike Daniel, Liman Labaran Mubarak

Journal of Pharmaceutical Research International · pp. 2631–2641 · Published 19 Nov 2014

10.9734/BJPR/2014/13071

Abstract

The seeds of Cola nitida were investigated for their anti-diabetic properties. The extracts were obtained by maceration in cold water. Alloxan was used to induce diabetes mellitus (DM) in the rats at 180mg/kg body weight and diabetes was confirmed after 48 hours. The Phytochemical analyses of the plants showed the presence of tannin, flavonoid, terpernoid, cardiac-gylcoside, and alkaloids. Anthraquinone and saponin were observed to be absent. Cola nitida was also observed to cause a reduction in blood glucose level from 599±0.667mg/dl (diabetic control) to 170±0.577mg/dl (extract treated group). The extract showed a significant (P<0.05) decrease of blood glucose level in alloxan induced diabetic rats. Cola nitida aqueous extract showed a higher level of potency when compared to a known anti-diabetic drug (Glanil).

Antidiabetic diabetes mellitus phytochemical Cola nitida

References (17)

  1. 1 A Colorimetric Method for the Determination of Serum Glutamic Oxalacetic and Glutamic Pyruvic Transaminases [DOI]
  2. 2 Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis
  3. 3 Diabetes and Cardiovascular Disease [DOI]
  4. 4 Phytochemical Studies And Comparative Efficacy Of The Crude Extracts Of Some Haemostatic Plants In Edo And Delta States Of Nigeria [DOI]
  5. 5 Diabetes Treatment — Bridging the Divide [DOI]
  6. 6 Clinical Chemistry and Metabolic Medicine, 7th edn. [DOI]
  7. 7 Coca-Cola, caffeine, and mental deficiency: Harry Hollingworth and the Chattanooga trial of 1911 [DOI]
  8. 8 Antidiabetic effect of diasulin, a herbal drug, on blood glucose, plasma insulin and hepatic enzymes of glucose metabolism in hyperglycaemic rats [DOI]
  9. 9 The State of Medicinal Plants Research in Nigeria [DOI]
  10. 10 Phytochemical and antioxidant screening of some plants of apocynaceae from South West Nigeria [DOI]
  11. 11 Evaluation of the Blood-Glucose Reducing Effects of Aqueous Extracts of the Selected Umbelliferous Fruits Used in Culinary Practices [DOI]
  12. 12 Effect of a poly-herbal formulation, Okudiabet, on alloxan-induced diabetic rats.
  13. 13 Antidiabetic Effect of Cleome droserifolia Aerial Parts: Lipid Peroxidation-Induced Oxidative Stress in Diabetic Rats [DOI]
  14. 14 Hypoglycemic Potencies of Crude Ethanolic Extracts of Cashew Roots and Unripe Pawpaw Fruits in Guinea Pigs and Rats [DOI]
  15. 15 Drug Therapy of Non-Insulin-Dependent Diabetes Mellitus in the Elderly [DOI]
  16. 16 Evaluation of an Enzymatic Procedure for Determination of Serum Cholesterol with the Abbott ABA-100 [DOI]
  17. 17 Current medical diagnosis & treatment [DOI]

Cited by 12

The Therapeutic Potential of Cola nitida in Health and Disease: A Review

K. O. Sanusi, U. Usman, Dawoud Usman · Biology, Medicine, & Natural Product Chemistry · 2024

Cola nitida infusion modulates cardiometabolic activities linked to cardiomyopathy in diabetic rats.

O. Erukainure, N. Msomi, Brian K. Beseni · Food and Chemical Toxicology · 2021

The antidiabetic properties of the hot water extract of kola nut (Cola nitida (Vent.) Schott & Endl.) in type 2 diabetic rats.

O. Erukainure, O. Sanni, O. Ijomone · Journal of Ethnopharmacology · 2019

Hyperglycemia-induced oxidative brain injury: Therapeutic effects of Cola nitida infusion against redox imbalance, cerebellar neuronal insults, and upregulated Nrf2 expression in type 2 diabetic rats.

O. Erukainure, Omamuyouwi M. Ijomone, O. Oyebode · Food and Chemical Toxicology · 2019

Caffeine - rich infusion from Cola nitida (kola nut) inhibits major carbohydrate catabolic enzymes; abates redox imbalance; and modulates oxidative dysregulated metabolic pathways and metabolites in Fe2+-induced hepatic toxicity.

O. Erukainure, O. Oyebode, Mxolisi K Sokhela · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017

Antidiabetic and toxicological properties of some African medicinal plants used in the treatment of diabetes and its complications.

O. Erukainure · 2018

UV-Vis scanning coupled with PCA as an alternative method for phytochemical screening of natural products – Costus Igneus leaf metabolites

S. Thiruchenduran, K. Maheswari, T. Prasad · 2017

Three decades of research efforts on the uses, conservation, and management of Cola nitida (Vent.): State of knowledge and prospects in Africa

Isabelle E.T. Tokannou, Souleymane Sanogo, Juliano S.H. Houndonougbo · Forestry Studies · 2024

Post-harvest quality assessment of freshly harvested and processed kola nuts [ Cola nitida (Vent.) Schott & Endl.] from selected growing regions in Ghana

Margaret Saka Aduama-Larbi, Ishmael Amoako-Attah, Winifred Oforiwaa Kumi · Cogent Food & Agriculture · 2022

Showing 9 of 12 known citations — external sources report more than can currently be individually listed.

Related research

Article metrics

Real usage data collected on this platform.

39

Page views

0

PDF downloads

16

Outbound clicks

12

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.