Phytochemical Screening and Hypoglycemic Effect of Aqueous Blighia sapida Root Bark Extract on Normoglycemic Albino Rats
A. N. Saidu, A. Mann, C. D. Onuegbu
Journal of Pharmaceutical Research International · pp. 89–97 · Published 2 Apr 2012
10.9734/BJPR/2012/1056Abstract
Aims: To carry out phytochemical screening and investigate hypoglycemic effect of aqueous Blighia sapida root bark extract (ABRE) on normoglycemic Albino rats. Study Design: Extraction and administration of bioactive extract. Place and Duration of Study: Department of Biochemistry, Federal University of Technology, Minna, Niger State, Nigeria, between June, 2010 and September, 2010. Methodology: Extraction of the air-dried ground root of Blighia sapida (100 g) was done with 80mls distilled water for 2 h. The extract (ABRE) obtained was then administered at concentrations of 100mg/ml and 200mg/ml per 1000g body weight of the rats. The normoglycemic albino rats were employed. Qualitative phytochemical screening was carried out according to the standard methods of Trease and Evans (2006). The animals were fed ad libitum with vital finisher made up of maize and soya beans mainly. Fasting blood taken after 16h over night fasting was used in this study. Results: The phytochemical screening of ABRE shows the presence of alkaloids, saponins, cardiac glycosides, reducing sugar, carbohydrates, flavonoids, phenol and tannin; while the test for protein showed negative results. Administration of the aqueous of B. sapida root bark at intervals of 48h for 21 days resulted in decrease in the blood glucose levels of rats. Conclusion: The findings of this study indicate that consumption of the ABRE exerts significant hypoglycemic effect in normoglycemic rats. These findings support the traditional use of ABRE for controlling diabetes. Further studies to isolate active principle(s) of the extracts as well as to elucidate their exact mechanism(s) of action are recommended.
References (43)
- 1 Medicinal plants and traditional medicine in Africa
- 2 Medicinal plants of India with anti-diabetic potential [DOI]
- 3 Medicinal Plants and Traditional Medicine in Africa [DOI]
- 4 Polyphenolic Flavanols as Scavengers of Aqueous Phase Radicals and as Chain-Breaking Antioxidants [DOI]
- 5 Antidiabetic plants and their active constituents [DOI]
- 6 Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus [DOI]
- 7 Uses and Properties ofCitrusFlavonoids [DOI]
- 8 Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats [DOI]
- 9 Veterans Affairs Cooperative Study on Glycemic Control and Complications in Type II Diabetes (VA CSDM): Results of the feasibility trial [DOI]
- 10 Traditional medicine development for medical and dental primary health care delivery system in Africa [DOI]
- 11 Medicinal plants with hypoglycemic activity [DOI]
- 12 Ethnobotanical studies of medicinal plants used in the management of diabetes mellitus in South Western Nigeria [DOI]
- 13 Fasting versus Gradual Initiation of the Ketogenic Diet: A Prospective, Randomized Clinical Trial of Efficacy [DOI]
- 14 Phytochemical and vitamin content of indigenous spices of South Eastern Nigeria
- 15 Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria [DOI]
- 16 The effect ofGongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats [DOI]
- 17 Antidiabetic and adaptogenic properties of Momordica charantia extract: An experimental and clinical evaluation [DOI]
- 18 Effect Of Walnut Leaf, Coriander And Pomegranate On Blood Glucose And Histopathology Of Pancreas Of Alloxan Induced Diabetic Rats [DOI]
- 19 Effect of shilajit on blood glucose and lipid profile in alloxan-induced diabetic rats
- 20 Vitamin C improves basal metabolic rate and lipid profile in alloxan-induced diabetes mellitus in rats [DOI]
- 21 DEMONSTRATION OF THE HYPOGLYCEMIC ACTION OF MOMORDICA CHARANTIA IN A VALIDATED ANIMAL MODEL OF DIABETES [DOI]
- 22 Hypoglycemic Activity of the Fruit of the Momordica charantia in Type 2 Diabetic Mice. [DOI]
- 23 Effect of Momordica charantia on Blood Glucose Level of Normal and Alloxan-Diabetic Rabbits [DOI]
- 24 Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats [DOI]
- 25 Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice [DOI]
- 26 Effect of Nauclea latifolia leaves aqueous extracts on blood glucose levels of normal and alloxan-induced diabetic rats [DOI]
- 27 Oral hypoglycaemic plants in West Africa [DOI]
- 28 Assessing Glycemic Control With Self-monitoring of Blood Glucose and Hemoglobin A1c Measurements [DOI]
- 29 Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control [DOI]
- 30 Evaluation of hypoglycaemic and hypolipidaemic effects of aqueous ethanolic extracts of Treculia africana Decne and Bryophyllum pinnatum,/i> Lam. and their mixture on streptozotocin (STZ)-induced diabetic rats [DOI]
- 31 Effects of oral administration of some herbal extracts on food consumption and blood glucose levels in normal and streptozotocin-treated diabetic rats [DOI]
- 32 Protective effect of Cassia glauca Linn. on the serum glucose and hepatic enzymes level in streptozotocin induced NIDDM in rats [DOI]
- 33 Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of morinda lucida benth. in normal and alloxan- induced diabetic rats [DOI]
- 34 Tropical Plants with Antihypertensive, Antiasthmatic, and Antidiabetic Value [DOI]
- 35 Preliminary studies of blood pressure lowering effect of Nauclea latifolia in rats [DOI]
- 36 Evaluation of the Phytochemical Composition and Hypoglycaemic Activity of Methanolic Leaves Extract of Costus afer in Albino Rats [DOI]
- 37 Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of morinda lucida benth. in normal and alloxan- induced diabetic rats [DOI]
- 38 Increased resting metabolic rate in patients with type 2 diabetes mellitus accompanied by advanced diabetic nephropathy [DOI]
- 39 Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria [DOI]
- 40 Effects of Hydromethanolic leaves extract of Indigofera pulchra on blood glucose levels of normoglycemic and alloxan-induced diabetic Wistar rats
- 41 Antihyperglycemic Effects of Fruits of Privet ( Ligustrum obtusifolium ) in Streptozotocin-Induced Diabetic Rats Fed a High Fat Diet [DOI]
- 42 Evaluation of the Phytochemical Composition and Hypoglycaemic Activity of Methanolic Leaves Extract of Costus afer in Albino Rats [DOI]
- 43 Ethnodietetics of Moringa oleifera leaves amongst the Ethnic Groups in Bida, Niger State, Nigeria and its Hypoglycaemic Effects in Rats
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