Preparation and Characterization of Mucoadhesive Buccal Film for Delivery of Meloxicam
A. R. Gardouh, M. M. Ghorab, S. S. Badawy, R. B. Gales
Journal of Pharmaceutical Research International · pp. 743–766 · Published 27 Jun 2013
10.9734/BJPR/2013/4288Abstract
Aims: Preparation of mucoadhesive buccal films able to deliver the meloxicam drug to the site of application through oral mucosal tissues. This dosage form is advantageous due to absence the problems of the ordinary dosage forms. Study Design: In this research, it was prepared a lot of formulations from different polymers and plasticizers to select the best one which has the optimum and required characteristics. Place and Duration of Study: Department of Pharmaceutics, Faculty of Pharmacy, Suez Canal University and Misr International University, Egypt, between July 2009 and July 2012. Methodology: There are different polymers used in preparation of the films which are hydroxypropylmethyl cellulose, hydroxyethyl cellulose, sodium carboxymethyl cellulose, pectin and polyvinyl alcohol. Also, the plasticizers used are glycerin, propylene glycol and polyethylene glycol. The film was prepared by solvent casting technique. Firstly, the calibration curve of meloxicam was carried out. Then, the properties of the formulations were examined through some experiments which are determination of drug content, study of efficacy of mucoadhesion, in-vitro drug release studies and differential scanning calorimetry. Results: It was found that the formula containing polyvinyl alcohol 2% (w/w) and propylene glycol 20% from the weight of the polymer has ideal characteristics. Results showed that this formula has optimum drug content, acceptable mucoadhesion and fast drug release with compatibility between drug and excipents.
References (47)
- 1 Pharmacotherapy: A Pathophysiologic Approach [DOI]
- 2 Mechanical, bioadhesive strength and biological evaluations of chitosan films for wound dressing.
- 3 Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC.
- 4 Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing [DOI]
- 5 Synthesis and Characterization of Pectin/PVP Hydrogel Membranes for Drug Delivery System [DOI]
- 6 Water-soluble binders for MCMB carbon anodes for lithium-ion batteries [DOI]
- 7 Characterization of cellulosic hot-melt extruded films containing lidocaine [DOI]
- 8 Formulation and Evaluation of Buccal Patches for Delivery of Atenolol [DOI]
- 9 Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid [DOI]
- 10 Pharmacology of Meloxicam, A New Non-Steroidal Anti-Inflammatory Drug with an Improved Safety Profile Through Preferential Inhibition of COX-2 [DOI]
- 11 Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole [DOI]
- 12 Micromatricial metronidazole benzoate film as a local mucoadhesive delivery system for treatment of periodontal diseases [DOI]
- 13 Synthesis and evaluation of the mucoadhesivity of a CD-chitosan derivative [DOI]
- 14 Polymeric Matrix System for Prolonged Delivery of Tramadol Hydrochloride, Part I: Physicochemical Evaluation [DOI]
- 15 Preparation, Characterization and In vitro Dissolution Studies of Solid Dispersion of Meloxicam with PEG 60001) [DOI]
- 16 Formulation and evaluation of nitrendipine buccal films [DOI]
- 17 DEVELOPMENT AND CHARACTERIZATION OF TRANSDERMAL PATCHES OF METOPROLOL TARTRATE
- 18 Evaluation of Synthesized Cross Linked Polyvinyl Alcohol as Potential Disintegrant [DOI]
- 19 Development of Mucoadhesive Buccal Films of Glipizide [DOI]
- 20 Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs [DOI]
- 21 Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying technique [DOI]
- 22 Physicochemical characterization of meloxicam–mannitol binary systems [DOI]
- 23 Solid dispersion of meloxicam: Factorially designed dosage form for geriatric population [DOI]
- 24 In vitro and in vivo evaluation of novel immediate release carbamazepine tablets: Complexation with hydroxypropyl-β-cyclodextrin in the presence of HPMC [DOI]
- 25 Solubility Enhancement of Cox-II Inhibitors by Cosolvency Approach [DOI]
- 26 An Examination of the Rheological and Mucoadhesive Properties of Poly(Acrylic Acid) Organogels Designed as Platforms for Local Drug Delivery to the Oral Cavity [DOI]
- 27 Optimization and Formulation of Orodispersible Tablets of Meloxicam [DOI]
- 28 Development and evaluation of buccoadhesive drug delivery system for Atorvastatin calcium
- 29 Formulation and evaluation of mucoadhesive glipizide films [DOI]
- 30 Development and evaluation of mucoadhesive buccal patches of flurbiprofen.
- 31 FORMULATION AND EVALUATION OF BUCCAL PATCHES OF VENLAFAXINE
- 32 Preparation and In Vitro Characterization of Mucoadhesive Polyvinyl Alcohol Microspheres Containing Amlodipine Besylate for Nasal Administration
- 33 Formulation and Evaluation of Mucoadhesive Buccal Film of Flurbiprofen
- 34 Blood-to-Brain Transfer of Various Oxicams: Effects of Plasma Binding on Their Brain Delivery [DOI]
- 35 Development of Polymer Film Dosage Forms of Lidocaine for Buccal Administration: II. Comparison of Preparation Methods [DOI]
- 36 Pectin-Based Bioadhesive Delivery of Carbenoxolone Sodium for Aphthous Ulcers in Oral Cavity [DOI]
- 37 Intraoral Delivery Systems [DOI]
- 38 Development and Evaluation of Mucoadhesive Chlorhexidine Tablet Formulations [DOI]
- 39 Solubility Enhancement of Meloxicam Prepared via Binary and Ternary Phases Using Spray Congealing
- 40 Formulation and In-vitro Evaluation of pH-Sensitive Oil Entrapped Polymeric Blend Amoxicillin Beads for the Eradication of Helicobacter pylori.
- 41 Formulation and Evaluation of Mucoadhesive Buccal Patches of Aceclofenac
- 42 Comparative Dissolution Studies of Marketed Preparations and Treatment of Data by Using ANOVA
- 43 Improvement of Dissolution Characteristics of Meloxicam by Complexation with Cyclodextrins [DOI]
- 44 Pharmacology and toxicology of COX-2 inhibitors [DOI]
- 45 Practical Uses of Differential Scanning Calorimetry for Plastics [DOI]
- 46 Dissolution studies and quantification of meloxicam in tablet dosage form by spectrophotometry.
- 47 DSC STUDIES ON THE STRUCTURAL CHANGE OF WATER RESTRAINED BY PECTINS [DOI]
Cited by 18
Anjoo Kamboj, M. Kaur, I. Bala · 2016
M. AlNimaAmina, Allahverdiev A.F., A. KhayrallahAhlam · 2014
Madhu Gudipati, N. Maruthi, P. Sai · 2023
Mahshid Arabi, S. Mortazavi, Zahra Jafariazar · Iranian journal of pharmaceutical research · 2020
Ajith Cherian, P. Daisy, Noby Thomas · 2015
N. Z. Yousif, Nidhal K. Maraie · 2015
M. Darwish · 2014
M. Darwish, A. K. Darwish · 2014
Related research
- Comparative Effect of Aspirin, Meloxicam and Terminalia catappa Leaf Extract on Serum Levels of Some Inflammatory Markers in Alloxan Induced Diabetic Rats — shares topic coverage
- Effect of Meloxicam on Hematological and Kidney Histopathological Changes in Male Mice — shares topic coverage
- Formulation and Evaluation of Colon Specific Meloxicam Microcapsules for the Treatment of Arthritis — shares topic coverage
- Formulation and Evaluation of Fluconazole Mucoadhisive Vaginal Tablets — shares topic coverage
- Current Mucoadhesive Drug Delivery System for Recurrent Aphthous Stomatitis — shares topic coverage
Article metrics
Real usage data collected on this platform.
45
Page views
0
PDF downloads
4
Outbound clicks
18
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.