Prevalence of Hepatitis D Virus among Hepatitis B Positive Blood Donors in Port Harcourt, Nigeria
Goodnews Nkabari Nwika, Jeremiah Zaccheus Awortu, Eze Evelyn Mgbeoma
International Blood Research & Reviews · pp. 48–56 · Published 24 Aug 2023
10.9734/ibrr/2023/v14i4317Abstract
Introduction: The Prevalence of Hepatitis D Virus among Blood Donors in Port Harcourt, Nigeria is a maiden epidemiological study of Hepatitis D or delta hepatitis among the donors’ population in Port Harcourt, Rivers State. Hepatitis D (Hepatitis Delta) is a disease caused by the hepatitis D virus (HDV). It is considered to be a sub viral satellite because it can propagate only in the presence of the hepatitis B virus. The prevalence of HDV in Port Harcourt has not been reported; hence this study, bridge that knowledge gap. Methods: Using a qualitative cross sectional study design, a general serological screening test was performed on a total of 300 blood donors recruited; 222(74.00%) males and 78 (26.00%) females, all within 20-59years. Of this number, 86(28.70%) were positive for HBV while 214(71.30%) Hepatitis B negative served as control. Samples collected were analysed at blood bank unit of the Haematology Department of the Rivers State University Teaching Hospital, Port Harcourt (RSUTH). Hepatitis B surface antigen (HBsAg), and anti-hepatitis D antibodies (anti-HDV) for the presence of HBV and HDV infections were detected by one step Hepatitis B surface antigen (HBsAg) in serum, and enzyme linked immunosorbent assay for the detection of HDV as described by the www.elabScience.com (16). Results: Of the 300 subjects, 86(28.6%) were positive for Hepatitis B surface antigen (HBsAg). Of these HBV positive subject, 9(10.4%) were positive for Hepatitis D virus (HDV). Age and gender of the study participants were not found to be risk factors for its prevalence (p > 0.05). There was no statistically significant difference in the PCV of those infected when compared with the non infected group. Using Pearson correlation analysis, HDV was not found to associate significantly with PCV (r = 0.2849, p > 0.05). This study recorded HDV prevalence rate of 10.4% among the HBsAg positive blood donors. Conclusion and Implications for Translation: There is a 10.4% prevalence of HDV among the HBsAg positive blood donors. To increase the safety level of blood products, the screening process should therefore be extended to the HDV.
References (12)
- 1 The global prevalence of hepatitis D virus infection: Systematic review and meta-analysis [DOI]
- 2 Prevalence and burden of hepatitis D virus infection in the global population: a systematic review and meta-analysis [DOI]
- 3 Estimating the Global Prevalence, Disease Progression, and Clinical Outcome of Hepatitis Delta Virus Infection [DOI]
- 4 Reducing the neglected burden of viral hepatitis in Africa: Strategies for a global approach [DOI]
- 5 Hepatitis B Virus and Hepatitis C Virus Infections in United States-Bound Refugees from Asia and Africa [DOI]
- 6 High Prevalence of Hepatitis B Virus Infection in the Age Range of 20-39 Years Old Individuals in Lome [DOI]
- 7 ICTV Virus Taxonomy Profile: Deltavirus [DOI]
- 8 Acute viral hepatitis – Should the current screening strategy be modified? [DOI]
- 9 Hepatitis delta virus infection in a large cohort of chronic hepatitis B patients in Ethiopia [DOI]
- 10 Prevalence and risk factors of Hepatitis D virus antibody among asymptomatic carriers of Hepatitis B virus: a community survey [DOI]
- 11 Prevalence and risk factors of hepatitis D virus infection in patients with chronic hepatitis B infection attending the three main tertiary hospitals in Libya [DOI]
- 12 Clade homogeneity and low rate of delta virus despite hyperendemicity of hepatitis B virus in Ethiopia [DOI]
Cited by 3
Nwika Goodnews Nkabari, Eze Evelyn Mgbeoma, Azuonwu Obioma, Ken-Ezihuo Stella U. · International Blood Research & Reviews · 2024
Victor Abiola Adepoju, Donald Chinazor Udah, Qorinah Estiningtyas Sakilah Adnani · Viruses · 2024
Showing 2 of 3 known citations — external sources report more than can currently be individually listed.
Related research
- Assessment of Exclusive Breastfeeding Practice among Palestinian Mothers in the Gaza Strip: A Mixed Methods Design — shares topic coverage
- Impact of the Diet Profile and Alcohol Consumption on Cardiometabolic Risks in Dschang Health District-Cameroon — shares topic coverage
- The Prevalence, Risk Factors and Awareness of Hypertension in an Urban Population of Dehradun, Uttarakhand, India — shares topic coverage
- ABO Blood Groups and Malaria Prevalence in a Referral Hospital in Nigeria — shares topic coverage
- Prevalence of Malaria among Pregnant Women and Children Under Five Years in Abi Local Government Area, Cross River State, Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
39
Page views
0
PDF downloads
4
Outbound clicks
3
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.