Protective Effects of Thespesia populnea (L.) Sol ex. Correa in Inflammatory, Nociceptive and Arthritic Conditions on Experimental Animals
P. S. Patil, P. D. Argade, R. S. Ghule, R. Venkatnarayanan, P. R. Shinde
Journal of Pharmaceutical Research International · pp. 215–227 · Published 9 Nov 2012
10.9734/BJPR/2012/1774Abstract
Aims: To evaluate the anti-inflammatory, antinociceptive and antiarthritis activities of methanolic extract of T. populnea flower (TPF) and root (TPR) extract; yet unreported. Study Design: Extraction and administration of bioactive extract. Place and Duration of Study: Department of Pharmacology and Department of Pharmacognosy, R.V.S. College of Pharmaceutical Science, Sulur, Coimbatore, Tamilnadu, India, between June 2010 and July 2011. Methodology: Thespesia populnea flowers and roots were extracted by soxhlet extraction using methanol. Anti-inflammatory activity of TPF and TPR was studied by using acetic acid induced vascular permeability and cotton-pellet granuloma. The antinociceptive activity of TPF and TPR was evaluated using formalin-induced paw licking response and the hot-plate test. The antiarthritic activity was studied by using adjuvant-induced arthritis model in rat. In addition total flavonoid content was determined with spectrophotometric method. Results: Administration of TPF and TPR (400 mg/kg) significantly (P < 0.01) decreased the formation of granuloma tissue induced by cotton pellet at a rate of 37.06% and 25.76% respectively. TPF and TPR inhibited acetic acid-induced vascular permeability in mice. In the adjuvant-induced arthritis test TPF and TPR inhibited 50.68% and 30.13% of paw thickness respectively. TPF and TPR also produced significant (P < 0.01) analgesic activity in formalin-induced paw licking response. In the hot-plate test, TPF and TPR have shown significantly (P < 0.01) increased in latency time when compared with control. Conclusion: Altogether, the present data demonstrate the anti-inflammatory antinociceptive and antiarthritis properties of flower and root of Thespesia populnea suggesting its potential role as adjuvant therapeutic tool for the management of inflammatory-related diseases.
References (29)
- 1 Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis
- 2 Pathologic Basis of Disease. [DOI]
- 3 Estimation of total flavonoid content in propolis by two complementary colometric methods [DOI]
- 4 The formalin test in mice: dissociation between inflammatory and non-inflammatory pain [DOI]
- 5 THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ANALGESICS [DOI]
- 6 Phytochemical compounds involved in the anti-inflammatory effect of propolis extract [DOI]
- 7 Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark [DOI]
- 8 PHASES OF THE INFLAMMATORY RESPONSE TO SUBCUTANEOUS IMPLANTATION OF A COTTON PELLET AND THEIR MODIFICATION BY CERTAIN ANTIINFLAMMATORY AGENTS [DOI]
- 9 Analgesic activity of Psychotria colorata (Willd. ex R. & S.) Muell. Arg. alkaloids [DOI]
- 10 Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract [DOI]
- 11 Antinociceptive activity of Zizyphus spina-christi root bark extract [DOI]
- 12 Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis [DOI]
- 13 Pharmacological actions of Thespesia populnea relevant to Alzheimer's disease [DOI]
- 14 Antioxidant activity of Thespesia populnea bark extracts against carbon tetrachloride-induced liver injury in rats [DOI]
- 15 Evaluation of the diuretic and analgesic activities of the rhizomes of Rumex abyssinicus Jacq in mice [DOI]
- 16 Anti-inflammatory activity of four solvent fractions of ethanol extract of Mentha spicata L. investigated on acute and chronic inflammation induced rats [DOI]
- 17 Biochemical aspects of inflammation [DOI]
- 18 ANTINOCICEPTIVE AND ANTI-INFLAMMATORY ACTIVITY OF THE SEED AND ROOT EXTRACTS OF FERULA GUMMOSA BOISS IN MICE AND RATS
- 19 Anti-inflammatory activity of ‘TAF’ an active fraction from the plant Barleria prionitis Linn. [DOI]
- 20 Anti-inflammatory activity of andrographolide
- 21 Preliminary studies on anti-inflammatory and analgesic activities of Securinega virosa (Euphorbiaceae) in experimental animal models [DOI]
- 22 Plants Used as Analgesics by Amazonian Caboclos as a Basis for Selecting Plants for Investigation [DOI]
- 23 Cytotoxicity and superoxide anion generation by some naturally occurring quinones [DOI]
- 24 Anti-inflammatory evaluation of Ionidium suffruticosam Ging. in rats [DOI]
- 25 Acute and chronic antiinflammatory effects of Hedera colchica in rats [DOI]
- 26 Hepatoprotective Activity of Thespesia populnea Bark Extracts against Carbon Tetrachloride-Induced Liver Toxicity in Rats
- 27 Antinociceptive effect of the aqueous extract of Balbisia calycina [DOI]
- 28 ANTIHYPERGLYCEMIC AND HYPOGLYCEMIC EFFECT OF THESPESIA POPULNEA FRUIT IN NORMAL AND ALLOXAN-INDUCED DIABETES IN RABBITS
- 29 Indian Medicinal Plants [DOI]
Cited by 2
Sobia Akram, Rahila Najam, Ghazala H. Rizwani · Pakistan Journal of Pharmaceutical Sciences · 2015
Mohan Kumar Pandiyan, Saravanan Thangavelu, Lalitha Vivekanandan · Medicinal and Aromatic Plants of the World · 2024
Related research
- Evaluation of In-vitro Anti-Inflammatory, Anti-Fungal, Thrombolytic, Membrane Stabilizing and Cytotoxic Properties of (Camellia chrysantha Hu Tuyama) — shares topic coverage
- Therapeutic Potential of Ginger-supplemented Diet in Reversing Lead-induced Nephrotoxicity — shares topic coverage
- Synthesis, Characterization and Biological Evaluation of Thiazolidinedione Substituted Derivatives — shares topic coverage
- Anti-inflammatory and Anti-infective Properties of Ethanol Leaf and Root Extracts of Baphia nitida — shares topic coverage
- Ethnopharmacological Properties of Ceasalpinia benthamiana - A Mini Review — shares topic coverage
Article metrics
Real usage data collected on this platform.
4
Page views
0
PDF downloads
0
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.