Psychiatric Presentation of a Severe Vitamin B12 Deficiency Associated with Biermer’s Disease: A Case Report
El Adraoui Yassine, Slimani Sarah, Mouloudi Najoua, Hamid Mohamed, Benmoh Youssouf, Bourazza Ahmed
International Journal of Medical and Pharmaceutical Case Reports · pp. 1–4 · Published 2 Jun 2024
10.9734/ijmpcr/2024/v17i3382Abstract
This case report highlights a 57-year-old female patient presenting with psychiatric symptoms such as depressive mood, social withdrawal, and apathy followed by gait disturbances and tremor, which led to the diagnosis of severe Vitamin B12 deficiency-induced encephalopathy. Despite initially displaying only psychiatric symptoms, MRI revealed cerebral leukoencephalopathy. Metabolic and auto-immune evaluation confirmed profound Vitamin B12 deficiency secondary to Biermer's disease. Treatment with Vitamin B12 replacement therapy resulted in a favorable outcome. This case underscores the importance of considering Vitamin B12 deficiency in patients with neuropsychiatric symptoms, as timely diagnosis and treatment can prevent long-term complications.
References (11)
- 1 Vitamin B12Deficiency [DOI]
- 2 Cobalamin Deficiency: Clinical Picture and Radiological Findings [DOI]
- 3 The Many Faces of Cobalamin (Vitamin B12) Deficiency [DOI]
- 4 Comprehensive review of Wernicke encephalopathy: pathophysiology, clinical symptoms and imaging findings [DOI]
- 5 Metabolic vitamin B12 deficiency: a missed opportunity to prevent dementia and stroke [DOI]
- 6 Laboratory assessment of vitamin B12 status [DOI]
- 7 Pernicious anemia: Pathophysiology and diagnostic difficulties [DOI]
- 8 What are the Psychiatric Manifestations of Vitamin B 12 Deficiency? [DOI]
- 9 Subtle vitamin-B12 deficiency and psychiatry: a largely unnoticed but devastating relationship? [DOI]
- 10 Vitamin B12Deficiency With Bilateral Globus Pallidus Abnormalities [DOI]
- 11 Neuropsychiatric manifestations of vitamin B12 and folate deficiencies: Data from an inpatient psychiatric department [DOI]
Cited by 2
Shakti Bedanta Mishra, Samir Samal, Sagarika Panda · Mastering ICU Care · 2025
Showing 1 of 2 known citations — external sources report more than can currently be individually listed.
Related research
- Influence of Treatment Parameters on Symptom Relief in Individuals with Vitamin B12 Deficiency — shares topic coverage
- Pseudo-Pelger-Huët Anomaly in Megaloblastic Anemia — shares topic coverage
- Comparative Efficacy of NASO B12 Versus Sublingual Methylcobalamin in Treating Vitamin B12 Deficiency: A Randomised Open-Label Clinical Trial — shares topic coverage
- Budd Chiari Syndrome Secondary to Pernicious Anemia: An Acquired Thrombophilia — shares topic coverage
- Vitamin B12 Deficiency: Biological Mechanisms, Diagnostic Developments and Evidence-supported Therapeutic Approaches: A Comprehensive Review — shares topic coverage
Article metrics
Real usage data collected on this platform.
30
Page views
0
PDF downloads
9
Outbound clicks
2
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.