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Research Article Open access CC BY 4.0

Regulation of Wnt Signaling by Heterotrimeric G-Proteins

S. Mahmoud A. Najafi

Asian Journal of Biology · pp. 59–73 · Published 11 Dec 2023

10.9734/ajob/2023/v19i4377

Abstract

Wnt signal transduction pathways play crucial roles in animal development, and after birth, they are involved in maintaining cellular and tissue homeostasis. Deregulation of the Wnt-mediated pathways occurs in many human diseases, including a wide range of human cancers. Many years ago, due to the topological similarity between Frizzled receptors and G-protein-coupled receptors, it was proposed that heterotrimeric G-proteins might be involved in the regulation of Wnt/Frizzled-mediated signaling pathways. Currently, there is a wealth of evidence indicating that heterotrimeric G-proteins regulate both canonical and non-canonical Wnt signaling pathways. This review article will discuss some of this evidence and the significance of this interaction.

Wnt signaling G proteins GPCR frizzled cancer

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