Serum Vitamin D Levels and Severity of Asthma in Children
Ahmadipour Shokoufeh, Mohsenzadeh Azam
Annual Research & Review in Biology · pp. 1–6 · Published 19 Aug 2015
10.9734/ARRB/2015/17370Abstract
Introduction: Asthma is a common chronic disease and it is a cause of attending the emergency department, hospitalization, and school absences in children. Several studies recorded in various countries report the increased prevalence of about 50% per decade for childhood asthma. Vitamin D is an essential vitamin which has effects on function of the immune system. There are Different and conflicting studies about the association between low concentration of vitamin D levels and severity of asthma in children. The aim of this study was to assess the relationship between serum vitamin D status and childhood asthma. Materials and Methods: In this analytical cross-sectional study, 134 children of 3-14 years old with asthma, who were hospitalized in 2014 in Madani Hospital in Khorramabad city, were investigated with regard to their age, gender, BMI, the use of inhaled corticosteroids, and serum levels of 25-Hydroxy Vitamin D. The variables and their possible association with vitamin D deficiency in patients were investigated, using the collected data from the questionnaires and laboratory exams. Findings: Mean age of the hospitalized children was 6.76±2.8 year. Mean serum vitamin D levels in children with asthma was, 58.8±24.7 mg/dL, regardless of its severity. Among all of the children with moderate persistent asthma, 13 subjects (52%) have had vitamin D deficiency and in children with mild persistent asthma, this value was 17.1%. In addition, 1.5% of the children with intermittent asthma have had serum vitamin D deficiency. According to Fisher's exact test, the difference in the frequency distribution of serum vitamin D status in children with asthma based on the severity of asthma was significant statistically (Pv<0.0001). In spite of lower serum vitamin D in obese and over-weighted children relative to the children with normal and low BMI, this difference was not statistically significant using one-way analysis of variance. Conclusion: In higher severities of asthma, vitamin D deficiency is more evident. Therefore, sufficient amounts of vitamin D supplementation may be effective in reducing the severity of asthma in children.
References (20)
- 1 Surveillance for asthma--United States, 1980-1999.
- 2 Family size, infection and atopy: the first decade of the 'hygiene hypothesis' [DOI]
- 3 Nelson Textbook of Pediatrics [DOI]
- 4 Is vitamin D deficiency to blame for the asthma epidemic? [DOI]
- 5 National hospital discharge survey: 2004 annual summary with detailed diagnosis and procedure data.
- 6 Vitamin D Levels, Lung Function, and Steroid Response in Adult Asthma [DOI]
- 7 National Hospital Discharge Survey: 2005 annual summary with detailed diagnosis and procedure data.
- 8 Vitamin D Serum Levels and Markers of Asthma Control in Italian Children [DOI]
- 9 Vitamin D Deficiency as a Strong Predictor of Asthma in Children [DOI]
- 10 Effect of Vitamin D and Inhaled Corticosteroid Treatment on Lung Function in Children [DOI]
- 11 The impact of vitamin D deficiency on immune T cells in asthmatic children: a case-control study [DOI]
- 12 Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents [DOI]
- 13 Validity and Reliability of Adult Recall of Past Sun Exposure in a Case-Control Study of Multiple Sclerosis [DOI]
- 14 The hygiene hypothesis and asthma [DOI]
- 15 Childhood asthma and vitamin D deficiency in Turkey: is there cause and effect relationship between them? [DOI]
- 16 Prospective Association of 25-Hydroxyvitamin D3 and D2 with Childhood Lung Function, Asthma, Wheezing, and Flexural Dermatitis [DOI]
- 17 Prospective Association of 25-Hydroxyvitamin D3 and D2 with Childhood Lung Function, Asthma, Wheezing, and Flexural Dermatitis [DOI]
- 18 The Peru Urban versus Rural Asthma (PURA) Study: methods and baseline quality control data from a cross-sectional investigation into the prevalence, severity, genetics, immunology and environmental factors affecting asthma in adolescence in Peru [DOI]
- 19 Association of Vitamin D–Related Information from a Telephone Interview with 25-Hydroxyvitamin D [DOI]
- 20 Investigating Asthma Deaths among Children and Young Adults: Michigan Asthma Mortality Review [DOI]
Cited by 3
M. Mardani, Sadegh Rezapour, S. Ahmadipour · Journal of Maternal-Fetal & Neonatal Medicine · 2017
M. Namdari, A. Eatemadi, M. Soleimaninejad · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2017
A. Mohsenzadeh, S. Ahmadipour, A. Farhadi · Nordic Journal of Psychiatry · 2017
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