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Research Article Open access CC BY 4.0

Severe Hemolytic Anemia Due to De novo Hemoglobin Sabine in an Argentinian Newborn. First Case in South America

Susana Perez, Irma Bragós, Mariana Raviola, Arianna Pratti, Germán Detarsio, Sandra Zirone, Maria Eda Voss, Luciano Verón, Irma Acosta, Mara Ojeda

International Blood Research & Reviews · pp. 166–170 · Published 2 Jun 2015

10.9734/IBRR/2015/18559

Abstract

Hemoglobin (Hb) Sabine is an unstable Hb variant that causes hemolytic anemia in heterozygous state, with inclusion bodies in the red blood cells (RBC). This hemoglobin is the result of a point mutation at codon 91(CTG)®(CCG) of the beta-globin gene. We report, for the first time in South America, the identification of Hb Sabine in a nine-month-old female baby, referred to our laboratory bearing a severe hemolytic anemia. We emphasize the need for the correct characterization of this unstable hemoglobin mainly for therapeutic purposes and for genetic counseling.  

Abnormal hemoglobin (Hb) Hb sabine unstable hemoglobin

References (6)

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  3. 3 [Hemolytic anemia due to hemoglobin Evans in an Argentinean family]. [DOI]
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Cited by 6

Severe hemolytic anemia due to combined α thalassemia and de novo Hemoglobin Sabine

XinPing Chen, JunJie Hu, Juan Zhu · Annals of Hematology · 2019

First report of familial hemolytic anemia due to hemoglobin Sabine in Asia

Kazuna Yamamoto, Kozue Nakamura, Ryosuke Shiozawa · Pediatrics International · 2022

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