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Research Article Open access CC BY 4.0

Sex Hormones, Oestrogen Receptor, Progesterone Receptor and Human Epithelial Receptor 2 Expressions in Pre and Postmenopausal Sub-Saharan African Women with Breast Cancer

Olulope O. Ajayi, Mabel A. Charles-Davies, John I. Anetor, Adeyinka F. Ademola

Journal of Cancer and Tumor International · pp. 1–11 · Published 17 May 2016

10.9734/JCTI/2016/25259

Abstract

Aim: This study was carried out to determine the serum levels of sex hormones and gonadotropins as well as the expression of oestrogen receptor (ER), progesterone receptor (PR) and human epithelial receptor 2 (HER 2) in pre and postmenopausal women with breast cancer. Study Design: Case-control study. Place and Duration of Study: Surgical Oncology Clinic, University College Hospital, Ibadan, Nigeria between April 2011 and July 2014. Methodology: 169 non-pregnant women aged 48.3±1.3 years were recruited for this study. They comprised of 85 histologically confirmed breast cancer pre-therapy (cases) matched with 84 apparently healthy women without breast cancer (controls) according to age and menstrual phase. Both cases and controls were subdivided into pre and postmenopausal groups (54 premenopausal cases; 31 postmenopausal cases; 53 premenopausal controls; 31 postmenopausal controls respectively). Anthropometry and reproductive history were obtained by standard methods. Blood (10ml) was obtained from participants and centrifuged to obtain serum. Oestradiol, progesterone, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were determined using enzyme immunoassay (EIA). Expression of ER, PR and HER 2 were determined by immunohistochemistry. Data analysed by Chi-square, Student’s t-test and multiple regression were considered statistically significant at p<0.05. Results: All premenopausal cases (100%) had ER and PR receptor negative expressions out of which 46(88.5%) had HER 2 receptor negative expression. Oestradiol and progesterone were significantly higher in postmenopausal cases compared with controls (p<0.05) while FSH and LH were significantly higher in premenopausal cases than controls (p<0.05). Conclusion: The pathophysiology of breast cancer may be based on menstrual phase. Elevated gonadotropins and sex hormones may be important in premenopausal and postmenopausal women with breast cancer. Triple negative breast cancer observed in 88.5% of premenopausal women with breast cancer is critical in the management of the disease especially in younger women.  

Breast cancer oestradiol progesterone gonadotropins hormone receptors enzyme immunoassay

References (49)

  1. 1 Estrogen and the Risk of Breast Cancer [DOI]
  2. 2 Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients [DOI]
  3. 3 Progesterone Receptor Status Significantly Improves Outcome Prediction Over Estrogen Receptor Status Alone for Adjuvant Endocrine Therapy in Two Large Breast Cancer Databases [DOI]
  4. 4 Endogenous Hormones and Breast Cancer Risk [DOI]
  5. 5 Prognostic Significance of Progesterone Receptor–Positive Tumor Cells Within Immunohistochemically Defined Luminal A Breast Cancer [DOI]
  6. 6 What aspects of body fat are particularly hazardous and how do we measure them? [DOI]
  7. 7 Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer. [DOI]
  8. 8 FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A [DOI]
  9. 9 Current issues in ER and HER2 testing by IHC in breast cancer [DOI]
  10. 10 Prognostic significance of progesterone receptor levels in estrogen receptor-positive patients with metastatic breast cancer treated with tamoxifen: results of a prospective Southwest Oncology Group study. [DOI]
  11. 11 Role of Hormones in Mammary Cancer Initiation and Progression [DOI]
  12. 12 Visceral adiposity, insulin resistance and cancer risk [DOI]
  13. 13 African ancestry and higher prevalence of triple‐negative breast cancer [DOI]
  14. 14 Predictive markers in breast cancer – the present [DOI]
  15. 15 Hormone receptor status and survival in a population‐based cohort of patients with breast carcinoma [DOI]
  16. 16 Early onset of breast cancer in a group of British black women [DOI]
  17. 17 Estrogen receptor negative/progesterone receptor positive breast cancer is not a reproducible subtype [DOI]
  18. 18 Progesterone receptor loss identifies Luminal B breast cancer subgroups at higher risk of relapse [DOI]
  19. 19 Joint detection of multiple immunohistochemical indices and clinical significance in breast cancer [DOI]
  20. 20 Breast Cancer [DOI]
  21. 21 Estradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells [DOI]
  22. 22 The diagnosis of breast cancer in women younger than 40 [DOI]
  23. 23 Role of Obesity in the Risk of Breast Cancer: Lessons from Anthropometry [DOI]
  24. 24 Rates for Breast Cancer Characteristics by Estrogen and Progesterone Receptor Status in the Major Racial/Ethnic Groups [DOI]
  25. 25 Time to Stop Progesterone Receptor Testing in Breast Cancer Management [DOI]
  26. 26 Fertility drugs and the risk of breast cancer: a meta-analysis and review [DOI]
  27. 27 Hip circumference is associated with the risk of premenopausal ER−/PR− breast cancer [DOI]
  28. 28 The influence of menstrual risk factors on tumor characteristics and survival in postmenopausal breast cancer [DOI]
  29. 29 Breast cancer in young women in Ibadan, Nigeria.
  30. 30 Indices of Metabolic Syndrome in 534 Apparently Healthy Nigerian Traders [DOI]
  31. 31 Hormone Therapy and the Brain [DOI]
  32. 32 Serum levels of sex hormones and breast cancer risk in premenopausal women: a case–control study (USA) [DOI]
  33. 33 A meta-analysis of the association between induced abortion and breast cancer risk among Chinese females [DOI]
  34. 34 Prediagnostic circulating follicle stimulating hormone concentrations and ovarian cancer risk [DOI]
  35. 35 Correlation of Hormone Receptor Expression with Histologic Parameters in Benign and Malignant Breast Tumors.
  36. 36 Does the increase of endogenous steroid hormone levels also affect breast cancer risk in Chinese women? A case–control study in Chongqing, China [DOI]
  37. 37 Association of Immunohistochemically Defined Molecular Subtypes with Clinical Response to Presurgical Chemotherapy in Patients with Advanced Breast Cancer [DOI]
  38. 38 Luteinizing Hormone Signaling and Breast Cancer: Polymorphisms and Age of Onset [DOI]
  39. 39 Insights Into the Role of Progesterone Receptors in Breast Cancer [DOI]
  40. 40 A prospective prognostic study of the hormonal milieu at the time of surgery in premenopausal breast carcinoma [DOI]
  41. 41 Serum follicle-stimulating hormone level is associated with human epidermal growth factor receptor type 2 and Ki67 expression in post-menopausal females with breast cancer [DOI]
  42. 42 Serum sex hormone levels in pre- and postmenopausal breast cancer patients.
  43. 43 Pathological predictive factors for tumor response in locally advanced breast carcinomas treated with anthracyclin-based neoadjuvant chemotherapy [DOI]
  44. 44 Reliability of follicle-stimulating hormone measurements in serum [DOI]
  45. 45 Circulating hormone levels in breast cancer patients. correlation with serum tumor markers and the clinical and biological features of the tumors.
  46. 46 Progesterone Receptor Testing: Not the Right Time to Be Buried [DOI]
  47. 47 Breast cancer receptor status assessment and clinicopathological association in Nigerian women: A retrospective analysis [DOI]
  48. 48 Sex Hormones and Their Relationship with Leptin and Cardiovascular Risk Factors in Pre and Post-Menopausal Nigerian Women with Metabolic Syndrome [DOI]
  49. 49 Relationship between the expression of ER,PR,Her-2 in breast cancer and its clinical pathological features

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