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Synthesis and Antimicrobial Activities of Novel Aminoalkylated 2H-benzotriazoles

Bharti Bhardwaj, Subhash C. Jain

Chemical Science International Journal · pp. 576–586 · Published 31 Mar 2014

10.9734/ACSJ/2014/9104

Abstract

In view of generating new compounds for future drug development, we have synthesized some N-aminoalkylated derivatives of benzo[d][1,2,3]triazole by alkylating benzo[d][1,2,3]triazole in the presence of K2CO3/DMF using 1,6-dibromohexane to obtain the 2-(6-bromohexyl)-2H-benzo[d][1,2,3]triazole (3) as the one of the major product which was then used as an intermediate to synthesize a new series of compounds 4a-j. All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities In vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermis), four Gram-negative bacteria (Echerichia coli, Pseudomonas aeuroginosa, Staphylococcus typhi and  Klebsiella pneumoniae) and four fungi (Aspergillus niger, Aspergillus fumigatus, Candida albicans and Aspergillus flavus) strains using Cup plate method.  

Antimicrobial activity benzo[d][1,2,3]triazole 1,6-dibromohexane aliphatic/ heterocyclic secondary amines

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Cited by 3

Benzotriazole: Much More Than Just Synthetic Heterocyclic Chemistry

Kiran Bajaj, Rajeev Sakhuja · Topics in Heterocyclic Chemistry · 2015

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