Synthesis and Antimicrobial Activities of Novel Aminoalkylated 2H-benzotriazoles
Bharti Bhardwaj, Subhash C. Jain
Chemical Science International Journal · pp. 576–586 · Published 31 Mar 2014
10.9734/ACSJ/2014/9104Abstract
In view of generating new compounds for future drug development, we have synthesized some N-aminoalkylated derivatives of benzo[d][1,2,3]triazole by alkylating benzo[d][1,2,3]triazole in the presence of K2CO3/DMF using 1,6-dibromohexane to obtain the 2-(6-bromohexyl)-2H-benzo[d][1,2,3]triazole (3) as the one of the major product which was then used as an intermediate to synthesize a new series of compounds 4a-j. All the synthesized compounds were fully characterized on the basis of their detailed spectral studies and were evaluated for their antimicrobial activities In vitro against three Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis and Staphylococcus epidermis), four Gram-negative bacteria (Echerichia coli, Pseudomonas aeuroginosa, Staphylococcus typhi and Klebsiella pneumoniae) and four fungi (Aspergillus niger, Aspergillus fumigatus, Candida albicans and Aspergillus flavus) strains using Cup plate method.
References (17)
- 1 Vogel's Textbook of Practical Organic Chemistry
- 2 Design, synthesis, and antifungal activity of triazole and benzotriazole derivatives [DOI]
- 3 Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease [DOI]
- 4 Structural features underlying selective inhibition of protein kinase CK2 by ATP site‐directed tetrabromo‐2‐benzotriazole [DOI]
- 5 Potential Drugs and Nondrugs: Prediction and Identification of Important Structural Features [DOI]
- 6 Halogenated Benzimidazoles and Benzotriazoles as Selective Inhibitors of Protein Kinases CK-I and CK-II from Saccharomyces Cerevisiae and Other Sources [DOI]
- 7 Antifilarial Activity of 1,3-Diarylpropen-1-One: Effect on Glutathione-S-Transferase, a Phase II Detoxification Enzyme [DOI]
- 8 1-Alkyl-benzotriazole-5-carboxylic Acids Are Highly Selective Agonists of the Human Orphan G-Protein-Coupled Receptor GPR109b [DOI]
- 9 Theoretical and Experimental Design of Atypical Kinase Inhibitors: Application to p38 MAP Kinase [DOI]
- 10 Physicochemical and biological characterization of novel macrocycles derived from o-phthalaldehyde [DOI]
- 11 Improved Synthesis of Benzotriazoles and 1-Acylbenzotriazoles by Ultrasound Irradiation [DOI]
- 12 Synthesis and anti-mycobacterial activities of triazoloquinolones [DOI]
- 13 Synthesis and antiproliferative activity of 3-aryl-2-(1H-benzotriazol-1-yl)acrylonitriles. Part III [DOI]
- 14 Synthesis and biological activity of benzotriazole derivatives structurally related to trazodone [DOI]
- 15 Facile One-Pot Synthesis of N-acyl-1H-1,2,3-benzotriazoles from Internal and Terminal Olefinic Fatty Acids and Their Antimicrobial Screening [DOI]
- 16 New aromatase inhibitors as second‐line endocrine therapy in postmenopausal patients with metastatic breast carcinoma [DOI]
- 17 A critical evaluation of molindone (Moban): a new indole derivative neuroleptic.
Cited by 3
Kiran Bajaj, Rajeev Sakhuja · Topics in Heterocyclic Chemistry · 2015
Showing 1 of 3 known citations — external sources report more than can currently be individually listed.
Related research
- Evaluation of Phytochemical Constituents and Antimicrobial Activity of Leaves and Stem Bark Extracts of Sarcocephalus latifolius — shares topic coverage
- Diversity and Antimicrobial Activity of Hydrobionts Associated Microorganisms from the Sea of Japan with the Occurrence of Tropodithietic Acid Producing Bacteria — shares topic coverage
- Antimicrobial Activity of Emilia pratermissa Leaf Extracts on Organisms Isolated from Patients with Otitis Media Attending Federal Medical Centre Owo and Ondo States Specialist Hospital Akure — shares topic coverage
- Molecular Identification, Bioactivity Screening and Metabolic Fingerprinting of the Actinomycetes of Chenab River Sediments — shares topic coverage
- Evaluating Efficacy of Biosurfactants from Bacterial Isolates in Conferring Protection against Rhizoctonia and Sclerotium Infection in Wheat and Peanut Plants — shares topic coverage
Article metrics
Real usage data collected on this platform.
14
Page views
0
PDF downloads
2
Outbound clicks
3
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.