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Research Article Open access CC BY 4.0

Synthesis and Antimicrobial Activity of Schiff’s and N-Mannich Bases of Indoline 2, 3-Dione and Its Derivatives with N-(4-(4-Aminophenylsulphonyl) Phenyl) Acetamide

Udit N. Soni, Anoop Singh

Journal of Pharmaceutical Research International · pp. 638–647 · Published 30 Dec 2021

10.9734/jpri/2021/v33i64B36014

Abstract

Indoline 2, 3-dione and substituted Indoline 2, 3-dione derivatives were reacted with N-(4-(4-aminophenylsulphonyl) phenyl) acetamide to generate a variety of Schiff's bases. Using these compounds' Mannich bases were created by reacting them with formaldehyde and secondary amine (piperidine). The compounds were all described using IR, 1H NMR spectroscopic data and elemental analysis. The antibacterial activity of the produced compounds was determined using the tube dilution and Well plate methods. When compound UNS-2 was incubated at concentrations of 100, 50, and 25mg/ml, it showed the greatest Zone of Inhibition against Enterococcus faecalis. When compared to the reference medication, all of the synthesised compounds demonstrated superior antimicrobial efficacy.

Indoline 2,3-dione Schiff’s bases Mannich bases antimicrobial activity

References (17)

  1. 1 Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4′-chlorophenyl)thiazol-2-yl] thiosemicarbazide [DOI]
  2. 2 Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives [DOI]
  3. 3 Anticonvulsant activity of Schiff bases of isatin derivatives.
  4. 4 Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives [DOI]
  5. 5 Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine [DOI]
  6. 6 Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one [DOI]
  7. 7 In vitro cytotoxicity evaluation of some substituted isatin derivatives [DOI]
  8. 8 Synthesis and structure–antituberculosis activity relationship of 1H-indole-2,3-dione derivatives [DOI]
  9. 9 Synthesis, antibacterial, antifungal and anti-HIV activities of norfloxacin Mannich bases [DOI]
  10. 10 Synthesis, Antibacterial, Antifungal and Anti-HIV Evaluation of Schiff and Mannich Bases of Isatin and its Derivatives with Triazole [DOI]
  11. 11 Synthesis and Screening for Anti-HIV Activity of Some N-Mannich Bases of Isatin Derivatives [DOI]
  12. 12 Synthesis and Antimicrobial Activity of Some New Isatin Derivatives [DOI]
  13. 13 Medical Bacteriology: a Practical Approach [DOI]
  14. 14 Anticonvulsant and Sedative-Hypnotic Activities of N-Acetyl / Methyl Isatin Derivatives [DOI]
  15. 15 Anti-Tubercular Activity of Isatin Derivatives
  16. 16 Antiviral, Antibacterial, and Antifungal Activities of Isatin N-Mannich Bases [DOI]
  17. 17 Synthesis and in-vitro cytotoxicity evaluation of Gatifloxacin Mannich bases [DOI]

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