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Research Article Open access CC BY 4.0

Synthesis, Characterization and Complexation Behaviour of Chloroquine towards Ti (II) Ion

I. E. Otuokere, L. O. Okpara, K. C. Amadi, C. O. Alisa, A. Okoyeagu, F. C. Nwadire

Journal of Pharmaceutical Research International · pp. 1–6 · Published 9 May 2019

10.9734/jpri/2019/v27i330168

Abstract

Aims: Chloroquine is a member of the drug class 4-aminoquinoline used for the prevention and treatment of malaria in areas where malaria is known to be sensitive to its effects. Our aim is to synthesize the chloroquine – titanium complex and to study its coordination behavior. Place and Duration of Study: Department of Chemistry, Michael Okpara University of Agriculture, Umudike, 2019. Methodology: Ti(II) complex of chloroquine was synthesized by the reaction of chloroquine phosphate with titanium(IV) oxide. The metal complex was characterized based on UV, IR and 1H NMR Spectroscopy. Results: The UV spectrum of the complex suggested intra ligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The IR spectrum of the complex showed the involvement of amine and imine group in coordination to Ti. This showed that chloroquine acted as a bidentate ligand. 1H NMR of the spectrum further showed the involvement of the amine group in coordination. Conclusion: The ability of chloroquine to sequestrate Ti (II) ion has been assured. This drug can be used to chelate Ti ions from solution, environment, and biological system.

Coordination ligand spectrum malaria chloroquine titanium

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Cited by 1

Spectroscopic and biological studies of mixed ligand complexes of transition metal (II) ions with chloroquine and ketoprofen

Yasmin M. S. Jamil, F. Al-Azab, N. Al-Selwi · مجلة جامعة صنعاء للعلوم التطبيقية والتكنولوجيا · 2024

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