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Research Article Open access CC BY 4.0

The Aquaporins: Regulator for Brain Pathophysiology

Nilofar Khan, Neetu Kushwah, Dipti Prasad

International Neuropsychiatric Disease Journal · pp. 29–37 · Published 28 Apr 2015

10.9734/INDJ/2015/17580

Abstract

Water transport is a fundamental process contributing to human physiology and pathophysiology. Water is primarily needed for all cell types but the water does not sit in the cells it moves through in very organized way. This process of movement is occurring through aquaporins. Aquaporins (AQPs) are expressed in tissues in which edema and fluid imbalances are of major concern. Three major water-channel proteins (AQP1, AQP4, AQP9) are expressed in brain. Potential roles of AQPs in brain are water homeostasis, edema, angiogenesis, cell migration and development. Beside their physiological expression patterns in the brain, AQPs are abnormally expressed in some pathological conditions e.g. cancer, neuroinflammatory diseases and neurodegenerative diseases, in which preservation of brain homeostasis is at risk. In mammalian brain, AQP4 water channels are localised in astroglial cells at the blood-brain-barrier interface; AQP1 channels are expressed in choroid plexus and serve in cerebral spinal fluid secretion. Some of glial cells and neurons also show the expression of AQPs though the function is still not known. These aquaporins being integral membrane proteins have an important role in various neurodegenerative diseases, thereby signifying their therapeutic importance. Furthermore the enhanced expression of AQP4 increases the water permeability of blood vessels which could be an important aspect for understanding the ill effects of hypoxia. Research in this field has significantly in last few years, and the review focuses on functional roles of AQPs in brain related to physiology and pathophysiology.

Aquaporins hypoxia neurodegeneration brain edema

References (55)

  1. 1 Specialized Membrane Domains for Water Transport in Glial Cells: High-Resolution Immunogold Cytochemistry of Aquaporin-4 in Rat Brain [DOI]
  2. 2 Astroglia induce neurogenesis from adult neural stem cells [DOI]
  3. 3 From structure to disease: the evolving tale of aquaporin biology [DOI]
  4. 4 Cellular and Molecular Biology of the Aquaporin Water Channels [DOI]
  5. 5 Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder [DOI]
  6. 6 A niche for adult neural stem cells [DOI]
  7. 7 Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord [DOI]
  8. 8 More than just water channels: unexpected cellular roles of aquaporins [DOI]
  9. 9 Cellular Mechanism of Oxygen Sensing [DOI]
  10. 10 Aquaporins in Brain: Distribution, Physiology, and Pathophysiology [DOI]
  11. 11 Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. [DOI]
  12. 12 Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin‐1 [DOI]
  13. 13 Glial cell abnormalities in major psychiatric disorders: the evidence and implications [DOI]
  14. 14 Astroglial Plasticity in the Hippocampus is Affected by Chronic Psychosocial Stress and Concomitant Fluoxetine Treatment [DOI]
  15. 15 The Aquaporin Water Channels [DOI]
  16. 16 Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression [DOI]
  17. 17 Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis [DOI]
  18. 18 Water homeostasis in the brain: Basic concepts [DOI]
  19. 19 Disruption of Aquaporin-11 Produces Polycystic Kidneys following Vacuolization of the Proximal Tubule [DOI]
  20. 20 Impaired Hearing in Mice Lacking Aquaporin-4 Water Channels [DOI]
  21. 21 Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus [DOI]
  22. 22 Aquaporin-1 Transports NO Across Cell Membranes [DOI]
  23. 23 Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells [DOI]
  24. 24 Brain Water Mobility Decreases after Astrocytic Aquaporin-4 Inhibition Using RNA Interference [DOI]
  25. 25 Inhibition of Aquaporin-1 and Aquaporin-4 Water Permeability by a Derivative of the Loop Diuretic Bumetanide Acting at an Internal Pore-Occluding Binding Site [DOI]
  26. 26 Hypoxia‐induced astrocytic reaction and increased vascular permeability in the rat cerebellum [DOI]
  27. 27 Aquaporins in Cerebrovascular Disease: A Target for Treatment of Brain Edema [DOI]
  28. 28 The AQP Structure and Functional Implications [DOI]
  29. 29 Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia [DOI]
  30. 30 Expression of aquaporin water channels in mouse spinal cord [DOI]
  31. 31 Distribution and possible roles of aquaporin 9 in the brain [DOI]
  32. 32 Radial glial origin of the adult neural stem cells in the subventricular zone [DOI]
  33. 33 Requirement of AQP4 for Antidepressive Efficiency of Fluoxetine: Implication in Adult Hippocampal Neurogenesis [DOI]
  34. 34 BRAIN OEDEMA FOLLOWING BRAIN ISCHAEMIA AND THE INFLUENCE OF THERAPY [DOI]
  35. 35 New Members of Mammalian Aquaporins: AQP10–AQP12 [DOI]
  36. 36 Aquaporins: Multiple Roles in the Central Nervous System [DOI]
  37. 37 Aquaporin 1 – a novel player in spinal cord injury [DOI]
  38. 38 Roles for novel pharmacological blockers of aquaporins in the treatment of brain oedema and cancer [DOI]
  39. 39 Cell locations for AQP1, AQP4 and 9 in the non-human primate brain [DOI]
  40. 40 AQP-4 in peritumoral edematous tissue is correlated with the degree of glioma and with expression of VEGF and HIF-alpha [DOI]
  41. 41 Aquaporin 1 is required for hypoxia-inducible angiogenesis in human retinal vascular endothelial cells [DOI]
  42. 42 Hypersensitivity of aquaporin 4-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine and astrocytic modulation [DOI]
  43. 43 Aquaporin‐4 Knockout Exacerbates Corticosterone‐Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis [DOI]
  44. 44 Transporters and Channels in Cytotoxic Astrocyte Swelling [DOI]
  45. 45 Oxygen-regulated transcription factors and their role in pulmonary disease [DOI]
  46. 46 Aquaporin(s) Expression in Choroid Plexus Tumours [DOI]
  47. 47 Unique expression and localization of aquaporin‐ 4 and aquaporin‐9 in murine and human neural stem cells and in their glial progeny [DOI]
  48. 48 Aquaporins and Neurodegenerative Diseases [DOI]
  49. 49 Cellular Niches for Endogenous Neural Stem Cells in the Adult Brain [DOI]
  50. 50 Aquaporin-Related Disorders of Water Homeostasis [DOI]
  51. 51 Aquaporins in the Kidney: From Molecules to Medicine [DOI]
  52. 52 Skeletal muscle function and water permeability in aquaporin-4 deficient mice [DOI]
  53. 53 Aquaporin Water Channels (Nobel Lecture) [DOI]
  54. 54 Physiological importance of aquaporin water channels [DOI]
  55. 55 Pathophysiology of the Aquaporin Water Channels [DOI]

Cited by 1

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