The Association of Adiponectin and AdipoR1 Polymorphism rs1342387 in Some Obesity-related Cancers in Kurdistan Iraq

Abstract

Background: Adiponectin (APN) is a novel hormone produced mainly by white adipose tissue that contribute to various physiological functions. APN has been related to cancer development specially the ones related to obesity such as breast cancer (BC) and colorectal cancer (CRC). Therefore, it also has been related body mass index (BMI). This study aims to investigate the role of APN and AdipoR1 polymorphism rs1342387 in some obesity-related cancer patients living in Erbil province (Kurdistan-Iraq). Method: The study includes 82 subjects (66 cancer patients, 16 healthy controls) from 4 medical facilities in Erbil, all participants were subjected to a questionnaire and signed a consent form before taking the samples. The serum level of APN was estimated by ELISA and the  AdipoR1 polymorphism (rs1342387) was detected by RFLP-PCR. Results: The results showed that the prevalence of BC cases were more than CRC cases. Furthermore, females were the dominant sex in BC. Moreover, the level of APN was significantly decreased in obesity-related cancer groups (BC, CRC) in compare to HC. Regarding APN correlation with BMI the results showed a weak non-significant negative correlation. The attempt to investigate the genotype of Kurdish people showed the frequency of GG genotype among Kurdish people but the recessive AA genotype showed more effects on decreasing the level of APN despite the non-significant results. Conclusion: This study is the first to investigate AdipoR1 polymorphism and its correlation to obesity-related cancers in Kurdistan-Iraq and although GG was the more frequent genotype, AA was more effective on APN levels in obesity-related cancers.