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Research Article Open access CC BY 3.0

The Effect of Leaf Aqueous Extract of Brachystegia eurycoma Harms (Fabaceae) in Acute and Chronic Inflammatory Animal Models

I. Igbe, G. O. Inarumen

Journal of Pharmaceutical Research International · pp. 391–400 · Published 12 Apr 2013

10.9734/BJPR/2013/2922

Abstract

Aims: To investigate the effect of the leaf extract of Brachystegia eurycoma Harms (Leguminosae) in acute and chronic Inflammatory animal models. Study Design: Extraction and anti-inflammatory evaluation. Place and Duration of Study: Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Benin. Methodology: The anti-inflammatory effect of the aqueous leaf extract of B. eurycoma Harm (Leguminosae) was evaluated using the carrageenan- and dextran-induced rat paw edema, xylene-induced ear edema and formalin-induced arthritis inflammation test. Results: In the carrageenan-induced paw edema, B. eurycoma at 100 mg/kg significantly (P<0.001) inhibited paw edema within four hours (1–4 h) The extract also produced significant inhibitory effects (P<0.05) at 200 mg/kg (1h and 4 h) and 400 mg/kg (2 h). B. eurycoma (100 mg/kg) produced a significant (P<0.01) inhibition of paw edema induced by dextran from 0 h and 4th h and at the 5th h (P<0.05) The extract (100 mg/kg) produced a significant inhibition (41.84 %, p<0.05) in the xylene induced ear edema model but in chronic inflammation (formalin induced arthritis) did not show any significant anti-inflammatory activity after seven (7) days. Oral acute toxicity assays did not show any mortality at 8 g/kg of the plant extract. Conclusion: These results suggest that the aqueous leaf extract of B. eurycoma possesses significant anti-inflammatory activity on acute inflammation but no effect on chronic inflammation, thus supporting the usage of the plant in traditional medicine treatment of inflammation.

Anti-inflammatory arthritis edema Brachystegia eurycoma.

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