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Research Article Open access CC BY 4.0

The Influence of Hemoglobin Variants on Plasmodium falciparum Parasite Density

Lamine MAHAMAN MOUSTAPHA, Mahamadou SEYNI YANSAMBOU, Ibrahim Halilou AMADOU, Anaëlle Deus-Maël Gloria Obubé ADJIVON, Adoum Fils SOULEYMANE, Maman Laminou IBRAHIM, Doutchi MAHAMADOU

Asian Journal of Biology · pp. 152–163 · Published 30 Dec 2024

10.9734/ajob/2024/v20i12468

Abstract

Malaria and sickle cell disease are public health problem in sub-Saharan Africa. We study the influence of hemoglobin type on parasite density in suspected sickle cell malaria patients in Maradi (Niger). This was a descriptive study with retrospective data collection between 2012 and 2023. Electrophoresis methods were used to determine the hemoglobin type and thick smear for the parasite density. This study included 875 participants with a sex ratio of 1.06 and a mean age of 14.25 years (range: 2 months to 80 years). Thick smear analysis of all participants revealed 52.91% positive, and the arithmetic mean of 242 p/uL (40 p/uL - 2600 p/uL). The most prevalent hemoglobin types were hemoglobin A (66.17%), following with hemoglobin S (29.14%) and hemoglobin C (3.66%). The geometric mean of the parasite density applied to the hemoglobin type shows that hemoglobin C (289.65 p/uL) and hemoglobin S (291.39 p/uL) stand out as being the highest. These results show that the differences in parasite density between hemoglobin A, hemoglobin S and hemoglobin C are statistically significant (p= 2.28x10-59). Regression analysis showed that hemoglobin C had a significant positive influence (p=0.029) on parasite density. The hemoglobin A2, hemoglobin F and hemoglobin S, did not have a statistically significant impact on parasite density. According to this study, person with predominant hemoglobin S and hemoglobin C have highest parasitemia than patients with predominant hemoglobin A type. It’s necessary to conduct others studies to determine the mechanism by how hemoglobin type affects parasite density in malaria.

Malaria sickle cell disease hemoglobin C parasite density

References (25)

  1. 1 Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis [DOI]
  2. 2 Mechanisms of genetically-based resistance to malaria [DOI]
  3. 3 Validation of isoleucine utilization targets in Plasmodium falciparum [DOI]
  4. 4 Resistance to Plasmodium falciparum in sickle cell trait erythrocytes is driven by oxygen-dependent growth inhibition [DOI]
  5. 5 Evolutionary history of sickle-cell mutation: implications for global genetic medicine [DOI]
  6. 6 Differing effects of HbS and HbC traits on uncomplicated falciparum malaria, anemia, and child growth [DOI]
  7. 7 Aberrant development of Plasmodium falciparum in hemoglobin CC red cells: implications for the malaria protective effect of the homozygous state [DOI]
  8. 8 Malaria in patients with sickle cell anaemia: burden, risk factors and outcome at the Laquintinie hospital, Cameroon [DOI]
  9. 9 Sickle Cell Hemoglobin Genotypes Affect Malaria Parasite Growth and Correlate with Exosomal miR-451a and let-7i-5p Levels [DOI]
  10. 10 Do Haematophagous Bugs Assess Skin Surface Temperature to Detect Blood Vessels? [DOI]
  11. 11 HEMOGLOBIN A: AN ELECTRON PARAMAGNETIC RESONANCE STUDY OF THE EFFECTS OF INTERCHAIN CONTACTS ON THE HEME SYMMETRY OF HIGH-SPIN AND LOW-SPIN DERIVATIVES OF FERRIC ALPHA CHAINS [DOI]
  12. 12 Haemoglobin S and haemoglobin C: 'quick but costly' versus 'slow but gratis' genetic adaptations to Plasmodium falciparum malaria [DOI]
  13. 13 Elevated Hemoglobin A2 as a Marker for .BETA.-Thalassemia Trait in Pregnant Women [DOI]
  14. 14 HbS Protection from P. falciparum Infection [DOI]
  15. 15 The Role of Hemoglobins C, S, and NBalt in the Inhibition of Malaria Parasite Development in Vitro [DOI]
  16. 16 Circulation of Non-falciparum Species in Niger: Implications for Malaria Diagnosis [DOI]
  17. 17 Protective hemoglobinopathies and Plasmodium falciparum transmission [DOI]
  18. 18 Hemoglobin A2 Levels in Malaria Patients [DOI]
  19. 19 Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1–Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C [DOI]
  20. 20 Acute Phase Responses Vary Between Children of HbAS and HbAA Genotypes During Plasmodium falciparum Infection [DOI]
  21. 21 Sickle Cell Disease and Severity of Malaria [DOI]
  22. 22 Plasmodium falciparum malaria and hospital associated visits among patients with hemoglobin variants attending general hospital Potiskum, Yobe State, Nigeria.
  23. 23 The Structure—Function Relationship of Hemoglobin in Solution at Atomic Resolution [DOI]
  24. 24 Malaria parasite density relationship with spleen size and fetal hemoglobin in Nigerian children with homozygous sickle cell disease [DOI]
  25. 25 Impact of sickle cell trait hemoglobin in Plasmodium falciparum -infected erythrocytes [DOI]

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