The Molecular Mechanisms of Magnesium Neuroprotection in Patients with Eclampsia: A Short Review
Amir Mor, Itai Gat, Reshef Tal, Mohamad Irani, Jigal Haas, Rotem Inbar, Hava Golan
Journal of Advances in Medicine and Medical Research · pp. 557–562 · Published 31 Dec 2014
10.9734/BJMMR/2015/14598Abstract
Eclampsia has been studied extensively over the last decades. Several pathophysiological mechanisms and animal models have been proposed for the disease. However, to date, none of them can fully explain the neuronal pathophysiology of eclamptic convulsions and the associated deleterious complications. Magnesium is the drug of choice for the prophylaxis and treatment of eclampsia in addition to prompt delivery. There is evidence to suggest that the beneficial effect of magnesium is exerted via modulation of the N-Methyl-D-Aspartate Receptor (NMDAR). The aim of this review is to explore the molecular mechanism by which magnesium exerts its neuroprotective effect and prevents eclamptic convulsions through the NMDAR activation pathway. Future investigations and alternative treatments are discussed.
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