Uncertainty of Treatment of Serratia marcescens Endocarditis
Melanie Goodberlet, Michael Schontz, Kevin McLaughlin, Julie Kelly
International Journal of Medical and Pharmaceutical Case Reports · pp. 1–5 · Published 17 Jun 2019
10.9734/ijmpcr/2019/v12i230100Abstract
Aim: To discuss two patient cases of Serratia marcescens endocarditis and the paucity of literature regarding treatment options. Presentation of Case: Patient 1 was a 29-year old male who presented with native mitral valve Serratia marcescens endocarditis presumed secondary to intravenous drug use. He was empirically treated with vancomycin and piperacillin/tazobactam then transitioned to meropenem and gentamicin 1 mg/kg every 8 hours. He was maintained on vancomycin monotherapy for days 4-14. Gentamicin was restarted on hospital day 14 at 7 mg/kg every 36 hours for 6 weeks. He underwent mitral valve replacement on hospital day 20. He was readmitted on day 42 with splenic lesions and enlarging mycotic aneurysms. Patient 2 was a 38-year old male with native aortic valve Serratia marcescens endocarditis with septic emboli presumed secondary to intravenous drug use. He was treated with vancomycin and cefepime then was transitioned to ceftriaxone and levofloxacin. The patient underwent aortic valve replacement on hospital day 3 and was transitioned to meropenem and levofloxacin for 6 weeks. Discussion: The treatment strategies for both patients demonstrates that the optimal treatment strategy for Serratia marcescens endocarditis remains unclear. The gentamicin dosing for patient 1 demonstrates “synergy” and extended-interval dosing. Despite both dosing strategies being used, the patient continued to exhibit complications of the infection. Patient 2 demonstrates successful treatment of the infection with surgical intervention and a carbapenem/fluoroquinolone regimen. Conclusion: These cases demonstrates that much remains unclear in the treatment of Serratia marcescens endocarditis and more studies and case reports are needed.
References (6)
- 1 Serratia Infections: from Military Experiments to Current Practice [DOI]
- 2 The Concept of an Ideal Antibiotic: Implications for Drug Design [DOI]
- 3 Serratia marcescens Endocarditis: A Regional Illness Associated with Intravenous Drug Abuse [DOI]
- 4 Serratia infections in a general hospital: characteristics and outcomes [DOI]
- 5 Intracranial abscess from embolic Serratia marcescens endocarditis [DOI]
- 6 Correction to: Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association [DOI]
Cited by 4
Sherif Elkattawy, Mahsa Mohammadian, Neil Williams · Cureus · 2021
· JAMA · 1970
· JAMA · 1970
Fabiana Duarte, Carina Machado, Luís Oliveira · Arquivos Brasileiros de Cardiologia · 2023
Related research
- Streptococcus gordonii: A Rare Cause of Infective Endocarditis with High Embolic Potential Revealed by Febrile Ischemic Stroke — shares topic coverage
- Epidemiological, Clinical, Etiological and Therapeutic Profile of Prosthesis Dysfunction — shares topic coverage
- Diagnostic Challenge of Fungal Prosthetic Valve Endocarditis: A Case Report — shares topic coverage
- Infective Endocarditis Revealing Laubry Pezzi Syndrome: A Rare Case Report — shares topic coverage
- Mitro-aortic Infective Endocarditis on Bicuspid Aortic Valve Complicated by Pseudoaneurysm of the Left Coronary Sinus: A Case Report — shares topic coverage
Article metrics
Real usage data collected on this platform.
20
Page views
0
PDF downloads
3
Outbound clicks
4
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.